9.A.14.11.3
GPRC5B of 403 aas and 8 TMSs in a 1 + 7 TMS arrangement. It is a players in controlling brain oedema (brain volume regulation) (Passchier et al. 2023). Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is the prototype. These findings shed light on the protein complex involved in astrocyte volume
regulation and identify GPRC5B as novel potentially druggable target for
treating brain oedema (asschier et al. 2023).
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| Accession Number: | CAC00632.1 |
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| Protein Name: | CAC00632.1 GPRC5B protein [Homo sapiens] |
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| Length: | 404 |
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| Molecular Weight: | |
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| Species: | Homo sapiens [9606] |
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| Number of TMSs: | 8 |
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| Substrate |
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1: MFVASERKMR AHQVLTFLLL FVITSVASEN ASTSRGCGLD LLPQYVSLCD LDAIWGIVVE
61: AVAGAGALIT LLLMLILLVR LPFIKEKEKK SPVGLHFLFL LGTLGLFGLT FAFIIQEDET
121: ICSVRRFLWG VLFALCFSCL LSQAWRVRRL VRHGTGPAGW QLVGLALCLM LVQVIIAVEW
181: LVLTVLRDTR PACAYEPMDF VMALIYDMVL LVVTLGLALF TLCGKFKRWK LNGAFLLITA
241: FLSVLIWVAW MTMYLFGNVK LQQGDAWNDP TLAITLAASG WVFVIFHAIP EIHCTLLPAL
301: QENTPNYFDT SQPRMRETAF EEDVQLPRAY MENKAFSMDE HNAALRTAGF PNGSLGKRPS
361: GSLGKRPSAP FRSNVYQPTE MAVVLNGGTI PTAPPSHTGR HLW