9.A.14.13.12
Proteinase-activated receptor-2 of 397 aas and 7 TMSs (δ group), F2RL1, GPR11, PAR2, or PAR-2.  Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. It can also be transactivated by cleaved F2R/PAR1. It is involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and it acts as a sensor for proteolytic enzymes generated during infection (Krumm and Grisshammer 2015). PAR-2, the second member of the G protein-coupled PAR family, is irreversibly activated by trypsin or tryptase and then targeted to lysosomes for degradation. Intracellular presynthesized receptors stored at the Golgi apparatus repopulate the cell surface after trypsin stimulation, thereby leading to rapid resensitization to trypsin signaling (Luo et al. 2007).  p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of PAR-2 by influencing receptor trafficking (Luo et al. 2007).