9.A.14.13.12 Proteinase-activated receptor-2 of 397 aas and 7 TMSs (δ group), F2RL1, GPR11, PAR2, or PAR-2. Receptor for trypsin and trypsin-like
enzymes coupled to G proteins. Its function is mediated through the
activation of several signaling pathways including phospholipase C
(PLC), intracellular calcium, mitogen-activated protein kinase (MAPK),
I-kappaB kinase/NF-kappaB and Rho. It can also be transactivated by cleaved
F2R/PAR1. It is involved in modulation of inflammatory responses and
regulation of innate and adaptive immunity, and it acts as a sensor for
proteolytic enzymes generated during infection (Krumm and Grisshammer 2015). PAR-2, the second member of the G protein-coupled PAR family, is irreversibly activated by trypsin or tryptase and then targeted to lysosomes for degradation. Intracellular presynthesized receptors stored at the Golgi apparatus repopulate the cell surface after trypsin stimulation, thereby leading to rapid resensitization to trypsin signaling (Luo et al. 2007). p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of PAR-2 by influencing receptor trafficking (Luo et al. 2007).
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Accession Number: | P55085 |
Protein Name: | Proteinase-activated receptor 2 |
Length: | 397 |
Molecular Weight: | 44126.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 7 |
Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
Substrate |
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1: MRSPSAAWLL GAAILLAASL SCSGTIQGTN RSSKGRSLIG KVDGTSHVTG KGVTVETVFS
61: VDEFSASVLT GKLTTVFLPI VYTIVFVVGL PSNGMALWVF LFRTKKKHPA VIYMANLALA
121: DLLSVIWFPL KIAYHIHGNN WIYGEALCNV LIGFFYGNMY CSILFMTCLS VQRYWVIVNP
181: MGHSRKKANI AIGISLAIWL LILLVTIPLY VVKQTIFIPA LNITTCHDVL PEQLLVGDMF
241: NYFLSLAIGV FLFPAFLTAS AYVLMIRMLR SSAMDENSEK KRKRAIKLIV TVLAMYLICF
301: TPSNLLLVVH YFLIKSQGQS HVYALYIVAL CLSTLNSCID PFVYYFVSHD FRDHAKNALL
361: CRSVRTVKQM QVSLTSKKHS RKSSSYSSSS TTVKTSY