9.A.14.13.14
The KiSS receptor (KiSSR) or G-protein receptor 54. Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated
peptide of KiSS1. KiSS1 is a metastasis suppressor protein that
suppresses metastases in malignant melanomas and in some breast
carcinomas without affecting tumorigenicity. Kisspeptin and GABA interact to modulate secretion and reproduction (Di Giorgio et al. 2019).
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| Accession Number: | Q969F8 |
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| Protein Name: | KiSS-1 receptor |
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| Length: | 398 |
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| Molecular Weight: | 42586.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MHTVATSGPN ASWGAPANAS GCPGCGANAS DGPVPSPRAV DAWLVPLFFA ALMLLGLVGN
61: SLVIYVICRH KPMRTVTNFY IANLAATDVT FLLCCVPFTA LLYPLPGWVL GDFMCKFVNY
121: IQQVSVQATC ATLTAMSVDR WYVTVFPLRA LHRRTPRLAL AVSLSIWVGS AAVSAPVLAL
181: HRLSPGPRAY CSEAFPSRAL ERAFALYNLL ALYLLPLLAT CACYAAMLRH LGRVAVRPAP
241: ADSALQGQVL AERAGAVRAK VSRLVAAVVL LFAACWGPIQ LFLVLQALGP AGSWHPRSYA
301: AYALKTWAHC MSYSNSALNP LLYAFLGSHF RQAFRRVCPC APRRPRRPRR PGPSDPAAPH
361: AELLRLGSHP APARAQKPGS SGLAARGLCV LGEDNAPL