9.A.14.13.16 The P2Y purinoreceptor 2, P2Y2 of 377 aas and 7 TMSs. Receptor for ATP and UTP coupled to
G-proteins that activate a phosphatidylinositol-calcium second messenger
system. The affinity range is UTP = ATP > ATP-gamma-S >>
2-methylthio-ATP = ADP. Plays a role in shedding (Pupovac and Sluyter 2016). There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14), and they play a variety of roles in cell physiology (von Kügelgen and Hoffmann 2016). The 3-d x-ray structure of a P2Y2 receptor is known (Jacobson et al. 2015). Antagonists stabilize an ionic lock within the P2T1
receptor, but binding of ADP breaks this ionic lock, forming a continuous water channel that
leads to P2Y1 receptor activation (Yuan et al. 2016).
|
Accession Number: | P41231 |
Protein Name: | P2Y purinoceptor 2 |
Length: | 377 |
Molecular Weight: | 42273.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 7 |
Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
Substrate |
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1: MAADLGPWND TINGTWDGDE LGYRCRFNED FKYVLLPVSY GVVCVPGLCL NAVALYIFLC
61: RLKTWNASTT YMFHLAVSDA LYAASLPLLV YYYARGDHWP FSTVLCKLVR FLFYTNLYCS
121: ILFLTCISVH RCLGVLRPLR SLRWGRARYA RRVAGAVWVL VLACQAPVLY FVTTSARGGR
181: VTCHDTSAPE LFSRFVAYSS VMLGLLFAVP FAVILVCYVL MARRLLKPAY GTSGGLPRAK
241: RKSVRTIAVV LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKV TRPLASANSC
301: LDPVLYFLAG QRLVRFARDA KPPTGPSPAT PARRRLGLRR SDRTDMQRIE DVLGSSEDSR
361: RTESTPAGSE NTKDIRL