9.A.14.13.19 The G-protein-coupled estrogen receptor, GPER (Gpr30; GPER1) of 375 aas and 7 TMSs. GPER binds to 17-beta-estradiol (E2) with high
affinity and aldosterone with lower affinity, leading to rapid and transient activation of numerous
intracellular signaling pathways. Activating GPR30 by estrogen results in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. Thus, GPR30 represents an intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology. It stimulates cAMP production, calcium
mobilization and tyrosine kinase Src (Gros et al. 2013; Gaudet et al. 2015).
|
Accession Number: | Q99527 |
Protein Name: | G-protein coupled estrogen receptor 1 |
Length: | 375 |
Molecular Weight: | 42248.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 7 |
Location1 / Topology2 / Orientation3: |
Nucleus1 |
Substrate |
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1: MDVTSQARGV GLEMYPGTAQ PAAPNTTSPE LNLSHPLLGT ALANGTGELS EHQQYVIGLF
61: LSCLYTIFLF PIGFVGNILI LVVNISFREK MTIPDLYFIN LAVADLILVA DSLIEVFNLH
121: ERYYDIAVLC TFMSLFLQVN MYSSVFFLTW MSFDRYIALA RAMRCSLFRT KHHARLSCGL
181: IWMASVSATL VPFTAVHLQH TDEACFCFAD VREVQWLEVT LGFIVPFAII GLCYSLIVRV
241: LVRAHRHRGL RPRRQKALRM ILAVVLVFFV CWLPENVFIS VHLLQRTQPG AAPCKQSFRH
301: AHPLTGHIVN LAAFSNSCLN PLIYSFLGET FRDKLRLYIE QKTNLPALNR FCHAALKAVI
361: PDSTEQSDVR FSSAV