9.A.14.13.29
Free fatty acid receptor-4, FFAR4, or GPR120, of 361 aas and 7 TMSs. GPR120 is a long-chain fatty acid receptor that stimulates incretin
hormone release from colonic endocrine cells and is implicated in
macrophage and adipocyte function (Watson et al. 2012). Cryo-EM structures have revealed how fatty acid hormones bind the orthosteric site within the 7 TMS domain within GPCRs (Mao et al. 2023). FFAR4 is a regulator of food and water intake (Apuschkin et al. 2024).
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| Accession Number: | Q5NUL3 |
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| Protein Name: | Free fatty acid receptor 4 |
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| Length: | 361 |
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| Molecular Weight: | 40494.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSPECARAAG DAPLRSLEQA NRTRFPFFSD VKGDHRLVLA AVETTVLVLI FAVSLLGNVC
61: ALVLVARRRR RGATACLVLN LFCADLLFIS AIPLVLAVRW TEAWLLGPVA CHLLFYVMTL
121: SGSVTILTLA AVSLERMVCI VHLQRGVRGP GRRARAVLLA LIWGYSAVAA LPLCVFFRVV
181: PQRLPGADQE ISICTLIWPT IPGEISWDVS FVTLNFLVPG LVIVISYSKI LQITKASRKR
241: LTVSLAYSES HQIRVSQQDF RLFRTLFLLM VSFFIMWSPI IITILLILIQ NFKQDLVIWP
301: SLFFWVVAFT FANSALNPIL YNMTLCRNEW KKIFCCFWFP EKGAILTDTS VKRNDLSIIS
361: G