9.A.14.13.31
Platelet P2Y purinoceptor 12, P2Y12 or P2YR12, of 342 aas and 7 TMSs. It is a receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. It is not activated by UDP and UTP. It is required for normal platelet aggregation and blood coagulation (Hollopeter et al. 2001). Clopidogrel is a potent antithrombotic drug that targets the P2Y12 receptor and inhibits ADP-induced platelet aggregation (Herbert and Savi 2003). The structure has been determined (Zhang et al. 2014) with and without agonist (Zhang et al. 2014).