9.A.14.13.33 Neuropeptide Y receptor type 2, NPYR2, of 381 aas and 7 TMSs. It is a receptor
for neuropeptide Y and peptide YY. The rank order of affinity of this
receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36)
> NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY >
PP, [Pro-34] PYY and NPY free acid. Neuropeptide Y (NPY) and NPY receptors are widely expressed in the
central nervous system, including the retina. Retinal cells express this peptide and its receptors (Y1, Y2, Y4 and/or Y5), and NPY is expressed in the retina of
various mammalian and non-mammalian species. Its early expression strongly suggests that NPY
may be involved in the development of retinal circuitry. NPY inhibits
the increase in [Ca2+]i, triggered by elevated KCl in retinal neurons, due to inhibition of Ca2+ channels, and it
protects retinal neural cells against toxic insults while inducing the
proliferation of retinal progenitor cells. Santos-Carvalho et al. 2014 reviewed the roles of NPY in the retina, specifically proliferation,
neuromodulation and neuroprotection. Alterations in the NPY system in
the retina might contribute to the pathogenesis of retinal degenerative
diseases, such as diabetic retinopathy and glaucoma.
|
Accession Number: | P49146 |
Protein Name: | Neuropeptide Y receptor type 2 |
Length: | 381 |
Molecular Weight: | 42731.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 7 |
Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
Substrate |
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1: MGPIGAEADE NQTVEEMKVE QYGPQTTPRG ELVPDPEPEL IDSTKLIEVQ VVLILAYCSI
61: ILLGVIGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN TLCLPFTLTY TLMGEWKMGP
121: VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR CIVYHLESKI SKRISFLIIG LAWGISALLA
181: SPLAIFREYS LIEIIPDFEI VACTEKWPGE EKSIYGTVYS LSSLLILYVL PLGIISFSYT
241: RIWSKLKNHV SPGAANDHYH QRRQKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSQVLDL
301: KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH SEVSVTFKAK
361: KNLEVRKNSG PNDSFTEATN V