9.A.14.13.34
The Duffy antigen, DARC or ACKR1, FY, GPD, of 336 aas and 7 TMSs. It is an atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. It is also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Almost the entire populations of DARC and three other transmembrane proteins are immobilized by either the incorporation within large multiprotein complexes or entrapment within the protein network of the cortical spectrin cytoskeleton (Kodippili et al. 2020).