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9.A.14.13.37
Protease-activated receptor_1 of 425 aas and 7 TMSs, PAR1, F2R, CF2R. It activates the KCNN3 channel. Dextran sodium sulfate (DSS) treatment causes loss of transient relaxations due to downregulation of SK3 channels (TC#1.A.1.16.7) and may increase contractile responses due to increased Ca2+ sensitization of smooth muscle cells via PAR1 activation (Sung et al. 2022). ().

Accession Number:P25116
Protein Name:Proteinase-activated receptor 1
Length:425
Molecular Weight:47441.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGPRRLLLVA ACFSLCGPLL SARTRARRPE SKATNATLDP RSFLLRNPND KYEPFWEDEE 
61:	KNESGLTEYR LVSINKSSPL QKQLPAFISE DASGYLTSSW LTLFVPSVYT GVFVVSLPLN 
121:	IMAIVVFILK MKVKKPAVVY MLHLATADVL FVSVLPFKIS YYFSGSDWQF GSELCRFVTA 
181:	AFYCNMYASI LLMTVISIDR FLAVVYPMQS LSWRTLGRAS FTCLAIWALA IAGVVPLLLK 
241:	EQTIQVPGLN ITTCHDVLNE TLLEGYYAYY FSAFSAVFFF VPLIISTVCY VSIIRCLSSS 
301:	AVANRSKKSR ALFLSAAVFC IFIICFGPTN VLLIAHYSFL SHTSTTEAAY FAYLLCVCVS 
361:	SISCCIDPLI YYYASSECQR YVYSILCCKE SSDPSSYNSS GQLMASKMDT CSSNLNNSIY 
421:	KKLLT