9.A.14.13.37
Protease-activated receptor_1 of 425 aas and 7 TMSs, PAR1, F2R, CF2R. It activates the KCNN3 channel. Dextran sodium sulfate (DSS) treatment causes loss of transient relaxations due to downregulation of SK3 channels (TC#1.A.1.16.7) and may increase contractile responses due to increased Ca2+ sensitization of smooth muscle cells via PAR1 activation (Sung et al. 2022).
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| Accession Number: | P25116 |
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| Protein Name: | Proteinase-activated receptor 1 |
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| Length: | 425 |
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| Molecular Weight: | 47441.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MGPRRLLLVA ACFSLCGPLL SARTRARRPE SKATNATLDP RSFLLRNPND KYEPFWEDEE
61: KNESGLTEYR LVSINKSSPL QKQLPAFISE DASGYLTSSW LTLFVPSVYT GVFVVSLPLN
121: IMAIVVFILK MKVKKPAVVY MLHLATADVL FVSVLPFKIS YYFSGSDWQF GSELCRFVTA
181: AFYCNMYASI LLMTVISIDR FLAVVYPMQS LSWRTLGRAS FTCLAIWALA IAGVVPLLLK
241: EQTIQVPGLN ITTCHDVLNE TLLEGYYAYY FSAFSAVFFF VPLIISTVCY VSIIRCLSSS
301: AVANRSKKSR ALFLSAAVFC IFIICFGPTN VLLIAHYSFL SHTSTTEAAY FAYLLCVCVS
361: SISCCIDPLI YYYASSECQR YVYSILCCKE SSDPSSYNSS GQLMASKMDT CSSNLNNSIY
421: KKLLT