9.A.14.13.38
Prokineticin receptor 1 (ProKR1) of 393 aas and 7 TMSs. Receptor for prokineticin 1. It is exclusively coupled to the G(q) subclass of
heteromeric G proteins. Activation leads to mobilization of calcium,
stimulation of phosphoinositide turnover and activation of p44/p42
mitogen-activated protein kinase. It may play a role during early
pregnancy (Evans et al. 2008). It is 87% identical to ProKR2, a receptor that binds the ligand prokineticin 2, involved in pleasant touch (Liu et al. 2022).
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| Accession Number: | Q8TCW9 |
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| Protein Name: | Prokineticin receptor 1 |
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| Length: | 393 |
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| Molecular Weight: | 44770.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: METTMGFMDD NATNTSTSFL SVLNPHGAHA TSFPFNFSYS DYDMPLDEDE DVTNSRTFFA
61: AKIVIGMALV GIMLVCGIGN FIFIAALVRY KKLRNLTNLL IANLAISDFL VAIVCCPFEM
121: DYYVVRQLSW EHGHVLCTSV NYLRTVSLYV STNALLAIAI DRYLAIVHPL RPRMKCQTAT
181: GLIALVWTVS ILIAIPSAYF TTETVLVIVK SQEKIFCGQI WPVDQQLYYK SYFLFIFGIE
241: FVGPVVTMTL CYARISRELW FKAVPGFQTE QIRKRLRCRR KTVLVLMCIL TAYVLCWAPF
301: YGFTIVRDFF PTVFVKEKHY LTAFYIVECI AMSNSMINTL CFVTVKNDTV KYFKKIMLLH
361: WKASYNGGKS SADLDLKTIG MPATEEVDCI RLK