9.A.14.13.39
N-arachidonyl glycine receptor, GPR18, of 331 aas and 7 TMSs. It is a receptor for endocannabinoid N-arachidonyl glycine (NAGly) (Flegel et al. 2016). It can also be activated by plant-derived and synthetic cannabinoid agonists (Console-Bram et al. 2014). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (Kohno et al. 2006). It may contribute to the regulation of the immune system.
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| Accession Number: | Q14330 |
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| Protein Name: | N-arachidonyl glycine receptor |
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| Length: | 331 |
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| Molecular Weight: | 38134.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MITLNNQDQP VPFNSSHPDE YKIAALVFYS CIFIIGLFVN ITALWVFSCT TKKRTTVTIY
61: MMNVALVDLI FIMTLPFRMF YYAKDEWPFG EYFCQILGAL TVFYPSIALW LLAFISADRY
121: MAIVQPKYAK ELKNTCKAVL ACVGVWIMTL TTTTPLLLLY KDPDKDSTPA TCLKISDIIY
181: LKAVNVLNLT RLTFFFLIPL FIMIGCYLVI IHNLLHGRTS KLKPKVKEKS IRIIITLLVQ
241: VLVCFMPFHI CFAFLMLGTG ENSYNPWGAF TTFLMNLSTC LDVILYYIVS KQFQARVISV
301: MLYRNYLRSM RRKSFRSGSL RSLSNINSEM L