9.A.14.13.40
G-protein-coupled receptor 183, GPR183, of 361 aas and 7 TMSs. This G-protein-coupled receptor is expressed in lymphocytes. It acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes. It is a receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (Hannedouche et al. 2011, Zhang et al. 2012). It mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient. Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses.  GPR183 is a chemotactic receptor with a function in the immune system, association with a variety of diseases. It recognizes ligands with diverse physicochemical properties, as both the endogenous oxysterol ligand 7α,25-OHC and synthetic molecules can activate the G protein pathway of the receptor.  Ligand entry pathways control the chemical space recognized by GPR183 (Kjær et al. 2023).