9.A.14.13.43
Hydroxycarboxylic acid receptor 3, HCAR3, of 387 aas and 7 TMSs. It is a receptor for 3-OH-octanoid acid and mediates a negative feedback regulation
of adipocyte lipolysis to counteract prolipolytic influences under
conditions of physiological or pathological increases in beta-oxidation
rates. It acts as a low affinity receptor for nicotinic acid, but this
pharmacological effect requires nicotinic acid doses that are much
higher than those provided by a normal diet (Wise et al. 2003; Ahmed et al. 2009). GPR109A interacts with hippuric acid (Bhandari et al. 2022).
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| Accession Number: | P49019 |
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| Protein Name: | Hydroxycarboxylic acid receptor 3 |
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| Length: | 387 |
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| Molecular Weight: | 44478.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MNRHHLQDHF LEIDKKNCCV FRDDFIAKVL PPVLGLEFIF GLLGNGLALW IFCFHLKSWK
61: SSRIFLFNLA VADFLLIICL PFVMDYYVRR SDWKFGDIPC RLVLFMFAMN RQGSIIFLTV
121: VAVDRYFRVV HPHHALNKIS NWTAAIISCL LWGITVGLTV HLLKKKLLIQ NGTANVCISF
181: SICHTFRWHE AMFLLEFFLP LGIILFCSAR IIWSLRQRQM DRHAKIKRAI TFIMVVAIVF
241: VICFLPSVVV RIHIFWLLHT SGTQNCEVYR SVDLAFFITL SFTYMNSMLD PVVYYFSSPS
301: FPNFFSTLIN RCLQRKITGE PDNNRSTSVE LTGDPNKTRG APEALIANSG EPWSPSYLGP
361: TSNNHSKKGH CHQEPASLEK QLGCCIE