9.A.14.13.44
n-Formyl peptide receptor-2, FRP2, of 351 aas and 7 TMSs, is a G-protein receptor.  It is a Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (Ye et al. 1992). Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (Ye et al. 1992). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4) (Gronert et al. 1998).  It is also a receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation. It also acts as a receptor for humanin (Harada et al. 2004). FPR2 agonist AnxA1 treatment resulted in the upregulation of the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway (Flores et al. 2023).