9.A.14.13.49
Ovarian cancer G-protein coupled receptor, OGR1 or GPR68 of 465 aas and 7 TMSs.  Proton-sensing receptor involved in pH homeostasis. It may represent an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. It also mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or Ca²⁺ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8, and it also functions as a metastasis suppressor gene in prostate cancer (Ludwig et al. 2003).  Functional expression of the proton sensors ASIC1a, TMEM206, and OGR1 together with BK_Ca channels is associated with cell volume changes and cell death (Pissas et al. 2024).