9.A.14.14.2
Methuselah (Mth) G-protein receptor. Involved in biological aging and stress responses. Essential for adult
survival. Required in the presynaptic motor neuron to up-regulate
neurotransmitter exocytosis at larval glutamatergic neuromuscular
junctions. Regulates a step associated with docking and
clustering of vesicles at release sites.
|
| Accession Number: | O97148 |
|---|
| Protein Name: | G-protein coupled receptor Mth |
|---|
| Length: | 514 |
|---|
| Molecular Weight: | 59644.00 |
|---|
| Species: | Drosophila melanogaster (Fruit fly) [7227] |
|---|
| Number of TMSs: | 7 |
|---|
| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
|
|---|
1: MKTLLVLRIS TVILVVLVIQ KSYADILECD YFDTVDISAA QKLQNGSYLF EGLLVPAILT
61: GEYDFRILPD DSKQKVARHI RGCVCKLKPC VRFCCPHDHI MDNGVCYDNM SDEELAELDP
121: FLNVTLDDGS VSRRHFKNEL IVQWDLPMPC DGMFYLDNRE EQDKYTLFEN GTFFRHFDRV
181: TLRKREYCLQ HLTFADGNAT SIRIAPHNCL IVPSITGQTV VMISSLICMV LTIAVYLFVK
241: KLQNLHGKCF ICYMVCLFMG YLFLLLDLWQ ISISFCKPAG FLGYFFVMAA FFWLSVISLH
301: LWNTFRGSSH KANRFLFEHR FLAYNTYAWG MAVVLTGITV LADNIVENQD WNPRVGHEGH
361: CWIYTQAWSA MLYFYGPMVF LIAFNITMFI LTAKRILGVK KDIQNFAHRQ ERKQKLNSDK
421: QTYTFFLRLF IIMGLSWSLE IGSYFSQSNQ TWANVFLVAD YLNWSQGIII FILFVLKRST
481: WRLLQESIRG EGEEVNNSEE EISLENTTTR NVLL