9.A.14.15.6
Probable G-protein coupled receptor 179, GPR179, of 2367 aas and 7 TMSs, possibly with one additional TMS at the N-terminus of the protein. The Cryo-EM structure of human class C orphan GPCR GPR179 is involved in visual processing (Yun et al. 2024). GPR179, an orphan class C GPCR, is expressed at the dendritic tips of
ON-bipolar cells in the retina. It plays a pivotal role in the initial
synaptic transmission of visual signals from photoreceptors, and its
deficiency is known to be the cause of complete congenital stationary
night blindness. The transmembrane domain (TMD) of GPR179 forms a homodimer through the
TM1/7 interface with a single inter-protomer disulfide bond, adopting a
noncanonical dimerization mode. The TMD dimer exhibits
architecture well-suited for the highly curved membrane of the dendritic
tip and distinct from the flat membrane arrangement observed in other
class C GPCR dimers. This structure reveals unique structural features of
GPR179 TMD, setting it apart from other class C GPCRs. These findings
provide a foundation for understanding signal transduction through
GPR179 in visual processing and offers insights into the underlying
causes of ocular diseases (Yun et al. 2024).
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| Accession Number: | Q6PRD1 |
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| Protein Name: | Probable G-protein coupled receptor 179 |
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| Length: | 2367 |
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| Molecular Weight: | 257363.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MGTRGAVMPP PMWGLLGCCF VCAWALGGPR PIRSLPPLSS QVKPGSVPMQ VPLEGAEAAL
61: AYLYSGDAQQ LSQVNCSERY EARGAGAMPG LPPSLQGAAG TLAQAANFLN MLLQANDIRE
121: SSVEEDVEWY QALVRSVAEG DPRVYRALLT FNPPPGASHL QLALQATRTG EETILQDLSG
181: NWVQEENPPG DLDTPALKKR VLTNDLGSLG SPKWPQADGY VGDTQQVRLS PPFLECQEGR
241: LRPGWLITLS ATFYGLKPDL SPEVRGQVQM DVDLQSVDIN QCASGPGWYS NTHLCDLNST
301: QCVPLESQGF VLGRYLCRCR PGFYGASPSG GLEESDFQTT GQFGFPEGRS GRLLQCLPCP
361: EGCTSCMDAT PCLVEEAAVL RAAVLACQAC CMLAIFLSML VSYRCRRNKR IWASGVVLLE
421: TVLFGFLLLY FPVFILYFKP SVFRCIALRW VRLLGFAIVY GTIILKLYRV LQLFLSRTAQ
481: RSALLSSGRL LRRLGLLLLP VLGFLAVWTV GALERGIQHA PLVIRGHTPS GRHFYLCHHD
541: RWDYIMVVAE LLLLCWGSFL CYATRAVLSA FHEPRYMGIA LHNELLLSAA FHTARFVLVP
601: SLHPDWTLLL FFFHTHSTVT TTLALIFIPK FWKLGAPPRE EMVDEVCEDE LDLQHSGSYL
661: GSSIASAWSE HSLDPGDIRD ELKKLYAQLE VHKTKEMAAN NPHLPKKRGS SCQGLGRSFM
721: RYLAEFPEAL ARQHSRDSGS PGHGSLPGSS RRRLLSSSLQ EPEGTPALHK SRSTYDQRRE
781: QDPPLLDSLL RRKLAKKASR TESRESVEGP PALGFRSASA HNLTVGERLP RARPASLQKS
841: LSVASSREKA LLMASQAYLE ETYRQAKERE ERKKAKAAMA SLVRRPSARR LERPRGAPLS
901: APPSPAKSSS VDSSHTSGRL HEEARRRLPH PPIRHQVSTP ILALSGGLGE PRMLSPTSTL
961: APALLPALAP TPAPALAPVP VSPQSPNLLT YICPWENAEL PAKQENVPQE GPSGPERGHH
1021: SPAPARARLW RALSVAVEKS RAGENEMDAE DAHHQREAND VDEDRPKIFP KSHSLKAPVQ
1081: QGSMRSLGLA IKALTRSRST YREKESVEES PEGQNSGTAG ESMGAPSRSP RLGRPKAVSK
1141: QAALIPSDDK ESLQNQQNAH TSRMLQVCQR EGSREQEDRG RRMTQGLGER KAERAGKTGL
1201: AMLRQVSRDK NIKQSKETPV GWQELPKAGL QSLGSADHRV AEVCPWEVTE SETRQPDSGN
1261: KAEICPWETS EGAPESRALR QDPGDSQKKR GEARGKSEPI DVVPMMRKKP ERLVREQEAV
1321: CPWESADRGG LSPGSAPQDP GRIRDKSEAG DSVEARKVEK PGWEAAGPEA HTPDITKAEP
1381: CPWEASEGGE DGKPAQEAVK DLPQEKQKTR KATFWKEQKP GGDLESLCPW ESTDFRGPSA
1441: VSIQAPGSSE CSGSLGSGIA EVCLWEAGDA PAIQKAEICP WELDDNVMGQ EMLSLGTGRE
1501: SLQEKEKASR KGSFGEMGEQ TVKAVQKLSQ QQESVCPRES TVPGHSSPCL DNSSSKAGSQ
1561: FLCNGGSRAT QVCPQEDLRP EAQEATPAKT EICPWEVNER TREEWTSAQV PRGGESQKDK
1621: EKMPGKSEIE DVTAWEKPEG QIQKQEAVGP WESVDPGSFS PQPRPQDTER PQTLLQMSGS
1681: VGSKAADICP LDVEENLTAG KAEICPWEVG AGAGEERALG AEAIRKSPND TGKVSADLGP
1741: RERAVTAPEK PQKPTPEWEV ACPWGSVGPG ACSQHPGTLD ADGPKAGFQE LDHMGCRPGE
1801: VCPWEAQEAA TSEKAKICPW EVSEGTTGKG LDQKAGSESA EQREKALEKG RLTSLGEDVS
1861: KGMAKLCQQQ ETICIWENKD LRESPAQAPK ISDLPSSMSS EVAEGHSLEA TEKGDLRQDP
1921: KTGSFPEHIT QEKAPAADTE EFTTEDGEKT SHELQSVCPW ETTAPADSVS HLDRQRPDQP
1981: KASSQRLVST GGRAADVCPW DVPDAGVYKS DSSAKAETCP WEVTERIPVK GVSRQDGKGD
2041: SQEEKGRAPE KSEPKGVPVQ KKPEMADFRQ QEAVCPWESQ DGKGLSPQPA PDASDRSRGS
2101: SEAAGSVETR VAEVCLWEVV EAPSAKKAEI CPWEAGGGAA EEGEQERESQ GQGEMFLQKA
2161: GPGGTEEHFS KAAAKPREQE AVCPGEGTGS GGLLPQSGAL DPELKVSPKE AGSMGSRMAE
2221: LCQWEITDPE GNKIKGTMAD ICPGEETGVP SEESGLLALT ATRREFFPTA PEKPLCLLVH
2281: GPLDHFFPES KIPCPKVSRP ASTFTLEGVR ELQGPSGLEP RTSLAPEPSL QEAESQSSSL
2341: TEDSGQVAFE AQYEEFTPPT VYPWDWE