9.A.14.16.1 Frizzled-1, FZD1 of 647 aas and 8 to 11 TMSs with 1 - 4 TMSs near the N-terminus, and 7 TMSs near the C-terminus. Receptor for Wnt proteins. Most of frizzled
receptors are coupled to the beta-catenin canonical signaling pathway,
which leads to the activation of disheveled proteins, inhibition of
GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt
target genes. A second signaling pathway involving PKC and calcium
fluxes has been seen for some family members. Association of Frizzled-6 from Drosophila melanogaster with CELSR1 (see TC# 9.A.14.6.4) is important, enabling efficient Frizzled-6 delivery to the
cell surface, providing a quality-control mechanism that ensures
appropriate stoichiometry of these two planar cell polarity (PCP)
proteins at cell boundaries (Tang et al. 2020).
|
Accession Number: | Q9UP38 |
Protein Name: | Frizzled-1 |
Length: | 647 |
Molecular Weight: | 71158.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 8 |
Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
Substrate |
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1: MAEEEAPKKS RAAGGGASWE LCAGALSARL AEEGSGDAGG RRRPPVDPRR LARQLLLLLW
61: LLEAPLLLGV RAQAAGQGPG QGPGPGQQPP PPPQQQQSGQ QYNGERGISV PDHGYCQPIS
121: IPLCTDIAYN QTIMPNLLGH TNQEDAGLEV HQFYPLVKVQ CSAELKFFLC SMYAPVCTVL
181: EQALPPCRSL CERARQGCEA LMNKFGFQWP DTLKCEKFPV HGAGELCVGQ NTSDKGTPTP
241: SLLPEFWTSN PQHGGGGHRG GFPGGAGASE RGKFSCPRAL KVPSYLNYHF LGEKDCGAPC
301: EPTKVYGLMY FGPEELRFSR TWIGIWSVLC CASTLFTVLT YLVDMRRFSY PERPIIFLSG
361: CYTAVAVAYI AGFLLEDRVV CNDKFAEDGA RTVAQGTKKE GCTILFMMLY FFSMASSIWW
421: VILSLTWFLA AGMKWGHEAI EANSQYFHLA AWAVPAIKTI TILALGQVDG DVLSGVCFVG
481: LNNVDALRGF VLAPLFVYLF IGTSFLLAGF VSLFRIRTIM KHDGTKTEKL EKLMVRIGVF
541: SVLYTVPATI VIACYFYEQA FRDQWERSWV AQSCKSYAIP CPHLQAGGGA PPHPPMSPDF
601: TVFMIKYLMT LIVGITSGFW IWSGKTLNSW RKFYTRLTNS KQGETTV