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9.A.14.16.3
Frizzled 6, FZD6 of 712 aas and 7 TMSs. FZD6  functions in multiple signal transduction pathways, for example, as a receptor in Wnt/planar cell polarity (PCP) signaling pathway for polarized cell migration and organ morphogenesis. Mutations in FZD6 have been identified in a variety of tumors (Zou et al. 2017).  Sfz6 mRNA is ubiquitously expressed, being highest in kidney and heart, and moderate in jejunum, ileum, colon, liver, and spleen.In the jejunum, FZD6 protein is more prevalent in the villus than in the crypt cells (Zou et al. 2017). FZD6 forms dimers, whose association is regulated by WNT proteins, and dimer dissociation is crucial for FZD6 signaling (Petersen et al. 2017).

Accession Number:F1S0R5
Protein Name:Frizzled class receptor 6
Length:712
Molecular Weight:80227.00
Species:Sus scrofa (Pig) [9823]
Number of TMSs:7
Substrate NONE

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEMFTFLWTC IFLPLIRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD QSIAAVEMEP 
61:	FLPLANLECS PNVETFLCKA FVPTCTEQID VVPPCRKFCE KVYSDCKKLM DTFGIRWPEE 
121:	LECNRLQYCD EPVPATFDPH TDFLSPQKKI EPVQRDIGFW CPRHLKTSGG QGYKFLGIDQ 
181:	CAPPCPNMYF KNDELEFAKS FIGIVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC 
241:	YSIVSLMYFI GFLLGNSTAC NKADEKLELG DTVVLGSQNK ACTVLFMFLY FFTMAGTVWW 
301:	VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGIPGFLTV MLLAMNKVEG DNISGVCFVG 
361:	LYDLDASRYF VLLPLCFCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF 
421:	SGLYLVPLVM LLGCYVYEQV NRITWEITWV SDHCRQYHIP CPYQAKTETR PELALFMMKY 
481:	LMTLIVGISA VFWVGSKKTC TEWAGFFKRN RKKDPISESR RVLQESCEFF LKHNSKVKHK 
541:	KKHYKPSSHK LKVISKSMGT STGATANHGT SAVAITNHDY LGQETLTEIQ TSPETSVREV 
601:	RADRASPPKA REQDGEDPAS SAASSSRLCG EQTDRKGRAG NVKDKSRVPA SARSEGRVTP 
661:	KNDGTETSPA PSNSLQAPSS SEPGSLKGST SLLVHSASGV RKEQGTGSHS DT