9.A.14.16.3
Frizzled 6, FZD6 of 712 aas and 7 TMSs. FZD6 functions in multiple signal transduction pathways, for example, as a receptor in Wnt/planar cell polarity (PCP) signaling pathway for polarized cell migration and organ morphogenesis. Mutations in FZD6 have been identified in a variety of tumors (Zou et al. 2017). Sfz6 mRNA is ubiquitously expressed, being highest in kidney and heart, and moderate in jejunum, ileum, colon, liver, and spleen.In the jejunum, FZD6 protein is more prevalent in the villus than in the crypt cells (Zou et al. 2017). FZD6 forms dimers, whose association is regulated by WNT proteins, and dimer dissociation is crucial for FZD6 signaling (Petersen et al. 2017).
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| Accession Number: | F1S0R5 |
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| Protein Name: | Frizzled class receptor 6 |
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| Length: | 712 |
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| Molecular Weight: | 80227.00 |
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| Species: | Sus scrofa (Pig) [9823] |
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| Number of TMSs: | 7 |
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| Substrate |
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1: MEMFTFLWTC IFLPLIRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD QSIAAVEMEP
61: FLPLANLECS PNVETFLCKA FVPTCTEQID VVPPCRKFCE KVYSDCKKLM DTFGIRWPEE
121: LECNRLQYCD EPVPATFDPH TDFLSPQKKI EPVQRDIGFW CPRHLKTSGG QGYKFLGIDQ
181: CAPPCPNMYF KNDELEFAKS FIGIVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC
241: YSIVSLMYFI GFLLGNSTAC NKADEKLELG DTVVLGSQNK ACTVLFMFLY FFTMAGTVWW
301: VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGIPGFLTV MLLAMNKVEG DNISGVCFVG
361: LYDLDASRYF VLLPLCFCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF
421: SGLYLVPLVM LLGCYVYEQV NRITWEITWV SDHCRQYHIP CPYQAKTETR PELALFMMKY
481: LMTLIVGISA VFWVGSKKTC TEWAGFFKRN RKKDPISESR RVLQESCEFF LKHNSKVKHK
541: KKHYKPSSHK LKVISKSMGT STGATANHGT SAVAITNHDY LGQETLTEIQ TSPETSVREV
601: RADRASPPKA REQDGEDPAS SAASSSRLCG EQTDRKGRAG NVKDKSRVPA SARSEGRVTP
661: KNDGTETSPA PSNSLQAPSS SEPGSLKGST SLLVHSASGV RKEQGTGSHS DT