TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.A.14.16.5
Frizzled, Fz, of 468 aas and 7 TMSs, a receptor for Wnt proteins. Involved in transcriptional regulation of synapse development (Mathew et al. 2005). It is a target of insecticides (Audsley and Down 2015). Its targeting from the ER to the plasma membrane has been studied (Tang et al., 2020; PMID# 33516494). ).

Accession Number:P18537
Protein Name:Frizzled
Length:581
Molecular Weight:64847.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MWRQILFILP TLIQGVQRYD QSPLDASPYY RSGGGLMASS GTELDGLPHH NRCEPITISI 
61:	CKNIPYNMTI MPNLIGHTKQ EEAGLEVHQF APLVKIGCSD DLQLFLCSLY VPVCTILERP 
121:	IPPCRSLCES ARVCEKLMKT YNFNWPENLE CSKFPVHGGE DLCVAENTTS SASTAATPTR 
181:	SVAKVTTRKH QTGVESPHRN IGFVCPVQLK TPLGMGYELK VGGKDLHDCG APCHAMFFPE 
241:	RERTVLRYWV GSWAAVCVAS CLFTVLTFLI DSSRFRYPER AIVFLAVCYL VVGCAYVAGL 
301:	GAGDSVSCRE PFPPPVKLGR LQMMSTITQG HRQTTSCTVL FMALYFCCMA AFAWWSCLAF 
361:	AWFLAAGLKW GHEAIENKSH LFHLVAWAVP ALQTISVLAL AKVEGDILSG VCFVGQLDTH 
421:	SLGAFLILPL CIYLSIGALF LLAGFISLFR IRTVMKTDGK RTDKLERLML RIGFFSGLFI 
481:	LPAVGLLGCL FYEYYNFDEW MIQWHRDICK PFSIPCPAAR APGSPEARPI FQIFMVKYLC 
541:	SMLVGVTSSV WLYSSKTMVS WRNFVERLQG KEPRTRAQAY V