9.A.14.16.7
Secreted frizzled-related protein 1, SFRP1, FRP-1, sFRP-1, secreted apoptosis-related protein 2, SARP-2 of 314 aas and 1 TMS. It is a potential target of oral squamous cell carcinoma (OSCC) (Chen et al. 2022). Highly expressed SFRP1 is associated with membrane potential and passive transmembrane transporter activity and is mainly enriched in calcium pathway and neuroactive ligand-receptor interactions (Chen et al. 2022). Thus, SFRP1 expression provides insight into the risk and prognostic stratification in OSCC. WTAP mediated m6A modification stabilizes
PDIA3P1 and promotes tumor progression driven by histone lactylation in esophageal squamous cell carcinoma (ESCC) (Huang et al. 2025).
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| Accession Number: | Q8N474 |
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| Protein Name: | Secreted frizzled-related protein 1 |
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| Length: | 314 |
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| Molecular Weight: | 35386.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: MGIGRSEGGR RGAALGVLLA LGAALLAVGS ASEYDYVSFQ SDIGPYQSGR FYTKPPQCVD
61: IPADLRLCHN VGYKKMVLPN LLEHETMAEV KQQASSWVPL LNKNCHAGTQ VFLCSLFAPV
121: CLDRPIYPCR WLCEAVRDSC EPVMQFFGFY WPEMLKCDKF PEGDVCIAMT PPNATEASKP
181: QGTTVCPPCD NELKSEAIIE HLCASEFALR MKIKEVKKEN GDKKIVPKKK KPLKLGPIKK
241: KDLKKLVLYL KNGADCPCHQ LDNLSHHFLI MGRKVKSQYL LTAIHKWDKK NKEFKNFMKK
301: MKNHECPTFQ SVFK