9.A.14.17.6
Bitter taste receptor, TAS2R46, of 309 aas and 7 TMSs. This receptor may play a role in the perception of bitterness and is
gustducin-linked. It may sense the chemical composition of
the gastrointestinal content. The activity of this receptor may
stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the
gating of TRPM5. In airway epithelial cells, binding
of bitter compounds increases the intracellular calcium ion
concentration and stimulates ciliary beat frequency. Most taste cells are activated by a limited number of bitter
compounds, and individual taste cells can discriminate among bitter stimuli. The structural basis for strychnine activation of TAS2R46 has been determined (Xu et al. 2022).
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| Accession Number: | P59540 |
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| Protein Name: | Taste receptor type 2 member 46 |
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| Length: | 309 |
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| Molecular Weight: | 35523.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MITFLPIIFS ILIVVTFVIG NFANGFIALV NSIEWFKRQK ISFADQILTA LAVSRVGLLW
61: VLVLNWYATE LNPAFNSIEV RITAYNVWAV INHFSNWLAT SLSIFYLLKI ANFSNLIFLH
121: LKRRVKSVVL VILLGPLLFL VCHLFVINMN QIIWTKEYEG NMTWKIKLRS AMYLSNTTVT
181: ILANLVPFTL TLISFLLLIC SLCKHLKKMQ LHGKGSQDPS MKVHIKALQT VTSFLLLCAI
241: YFLSIIMSVW SFESLENKPV FMFCEAIAFS YPSTHPFILI WGNKKLKQTF LSVLWHVRYW
301: VKGEKPSSS