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Accession Number: | P21453 |
Protein Name: | Sphingosine 1-phosphate receptor 1 |
Length: | 382 |
Molecular Weight: | 42811.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 7 |
Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
Substrate |
Cross database links:
Entrez Gene ID: | 1901 |
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Pfam: | PF00001 |
KEGG: | hsa:1901 hsa:1901 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0038036
F:sphingosine-1-phosphate receptor activity
GO:0007155
P:cell adhesion
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References (22)[1] “An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.” Hla T.et.al. 2160972 [2] “Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.” An S.et.al. 9409733 [3] “Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.” Parrill A.L.et.al. 10982820 [4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [5] “The DNA sequence and biological annotation of human chromosome 1.” Gregory S.G.et.al. 16710414 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.” Lee M.-J.et.al. 8626678 [8] “Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.” Lee M.-J.et.al. 9488656 [9] “Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.” Ancellin N.et.al. 10383399 [10] “Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.” Lee M.-J.et.al. 11583630 [11] “Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.” Hobson J.P.et.al. 11230698 [12] “An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.” Hla T.et.al. 2160972 [13] “Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.” An S.et.al. 9409733 [14] “Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.” Parrill A.L.et.al. 10982820 [15] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [16] “The DNA sequence and biological annotation of human chromosome 1.” Gregory S.G.et.al. 16710414 [17] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [18] “The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.” Lee M.-J.et.al. 8626678 | |
Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MGPTSVPLVK AHRSSVSDYV NYDIIVRHYN YTGKLNISAD KENSIKLTSV VFILICCFII 61: LENIFVLLTI WKTKKFHRPM YYFIGNLALS DLLAGVAYTA NLLLSGATTY KLTPAQWFLR 121: EGSMFVALSA SVFSLLAIAI ERYITMLKMK LHNGSNNFRL FLLISACWVI SLILGGLPIM 181: GWNCISALSS CSTVLPLYHK HYILFCTTVF TLLLLSIVIL YCRIYSLVRT RSRRLTFRKN 241: ISKASRSSEK SLALLKTVII VLSVFIACWA PLFILLLLDV GCKVKTCDIL FRAEYFLVLA 301: VLNSGTNPII YTLTNKEMRR AFIRIMSCCK CPSGDSAGKF KRPIIAGMEF SRSKSDNSSH 361: PQKDEGDNPE TIMSSGNVNS SS