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9.A.14.2.1
Sphingosine 1-phosphate receptor, Edg1, Edg-1, CHEDG1 or S1PR1. The 3-d structure in known (Hanson et al., 2012). The activation mechanism has been proposed (Caliman et al. 2017). It plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase, SPHK1. It is also required for normal chemotaxis toward sphingosine 1-phosphate. Finally it is involved in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells (Singleton et al. 2009; Hanson et al. 2012).

Accession Number:P21453
Protein Name:Sphingosine 1-phosphate receptor 1
Length:382
Molecular Weight:42811.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 1901   
Pfam: PF00001   
KEGG: hsa:1901    hsa:1901   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0038036 F:sphingosine-1-phosphate receptor activity
GO:0007155 P:cell adhesion

References (22)

[1] “An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.”  Hla T.et.al.   2160972
[2] “Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.”  An S.et.al.   9409733
[3] “Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.”  Parrill A.L.et.al.   10982820
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.”  Lee M.-J.et.al.   8626678
[8] “Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.”  Lee M.-J.et.al.   9488656
[9] “Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.”  Ancellin N.et.al.   10383399
[10] “Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.”  Lee M.-J.et.al.   11583630
[11] “Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.”  Hobson J.P.et.al.   11230698
[12] “An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.”  Hla T.et.al.   2160972
[13] “Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.”  An S.et.al.   9409733
[14] “Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.”  Parrill A.L.et.al.   10982820
[15] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[16] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[17] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[18] “The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.”  Lee M.-J.et.al.   8626678
[19] “Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.”  Lee M.-J.et.al.   9488656
[20] “Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.”  Ancellin N.et.al.   10383399
[21] “Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.”  Lee M.-J.et.al.   11583630
[22] “Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.”  Hobson J.P.et.al.   11230698
Structure:
3V2W   3V2Y     

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FASTA formatted sequence 
1:	MGPTSVPLVK AHRSSVSDYV NYDIIVRHYN YTGKLNISAD KENSIKLTSV VFILICCFII 
61:	LENIFVLLTI WKTKKFHRPM YYFIGNLALS DLLAGVAYTA NLLLSGATTY KLTPAQWFLR 
121:	EGSMFVALSA SVFSLLAIAI ERYITMLKMK LHNGSNNFRL FLLISACWVI SLILGGLPIM 
181:	GWNCISALSS CSTVLPLYHK HYILFCTTVF TLLLLSIVIL YCRIYSLVRT RSRRLTFRKN 
241:	ISKASRSSEK SLALLKTVII VLSVFIACWA PLFILLLLDV GCKVKTCDIL FRAEYFLVLA 
301:	VLNSGTNPII YTLTNKEMRR AFIRIMSCCK CPSGDSAGKF KRPIIAGMEF SRSKSDNSSH 
361:	PQKDEGDNPE TIMSSGNVNS SS