9.A.14.2.7
G-protein coupled receptor, GPR3 or ACCA, of 330 aas and 7 TMSs.  It is an orphan receptor with constitutive G(s) signaling activity that activates cyclic AMP. It has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons and neurite outgrowth. It maintains meiotic arrest in oocytes.  It is the most cold-induced G-coupled receptor in both brown and beige thermogenic adipose tissues. It has high basal Gs-coupled activity in the absence of an exogenous ligand (Sveidahl Johansen et al. 2021). It mimicks the cold induction of Gpr3 triggered cAMP production, activates the thermogenic response and counteracts meetabolic disease. A disease-associated genetic variant of GPR3 in patient-derived adiposctes revealed that GPR3 acts as a regulator of human thermogenic adipose tissue (Sveidahl Johansen et al. 2021).