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9.A.14.21.1
The G-protein-coupled bile acid receptor of 330 aas and 7 TMSs, GPCR19. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids (Maruyama et al. 2002; Kawamata et al. 2003; Häussinger and Kordes 2017).

Accession Number:Q8TDU6
Protein Name:G-protein coupled bile acid receptor 1
Length:330
Molecular Weight:35248.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Structure:
7BW0   7CFM   7CFN     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MTPNSTGEVP SPIPKGALGL SLALASLIIT ANLLLALGIA WDRRLRSPPA GCFFLSLLLA 
61:	GLLTGLALPT LPGLWNQSRR GYWSCLLVYL APNFSFLSLL ANLLLVHGER YMAVLRPLQP 
121:	PGSIRLALLL TWAGPLLFAS LPALGWNHWT PGANCSSQAI FPAPYLYLEV YGLLLPAVGA 
181:	AAFLSVRVLA TAHRQLQDIC RLERAVCRDE PSALARALTW RQARAQAGAM LLFGLCWGPY 
241:	VATLLLSVLA YEQRPPLGPG TLLSLLSLGS ASAAAVPVAM GLGDQRYTAP WRAAAQRCLQ 
301:	GLWGRASRDS PGPSIAYHPS SQSSVDLDLN