9.A.14.22.2
Putative G-protein receptor of 600 aas and 7 TMSs, GPR107. It has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (Yosten et al. 2012). It is also involved in blood sugar regulation through the induction of glucagon in response to low glucose. It is required for intoxication by Pseudomonas aeruginosa exotoxin
A and Campylobacter jejuni CDT. It may also contribute to the retrograde
transport of bacterial toxins, including cholera toxin, from the
trans-Golgi network to the endoplasmic reticulum (Tafesse et al. 2014).
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| Accession Number: | Q5VW38 |
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| Protein Name: | Protein GPR107 |
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| Length: | 600 |
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| Molecular Weight: | 66990.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Golgi apparatus1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MAALAPVGSP ASRGPRLAAG LRLLPMLGLL QLLAEPGLGR VHHLALKDDV RHKVHLNTFG
61: FFKDGYMVVN VSSLSLNEPE DKDVTIGFSL DRTKNDGFSS YLDEDVNYCI LKKQSVSVTL
121: LILDISRSEV RVKSPPEAGT QLPKIIFSRD EKVLGQSQEP NVNPASAGNQ TQKTQDGGKS
181: KRSTVDSKAM GEKSFSVHNN GGAVSFQFFF NISTDDQEGL YSLYFHKCLG KELPSDKFTF
241: SLDIEITEKN PDSYLSAGEI PLPKLYISMA FFFFLSGTIW IHILRKRRND VFKIHWLMAA
301: LPFTKSLSLV FHAIDYHYIS SQGFPIEGWA VVYYITHLLK GALLFITIAL IGTGWAFIKH
361: ILSDKDKKIF MIVIPLQVLA NVAYIIIEST EEGTTEYGLW KDSLFLVDLL CCGAILFPVV
421: WSIRHLQEAS ATDGKGDSMG PLQQRANLRA GSRIESHHFA QADLELLASS CPPASVSQRA
481: GITAAINLAK LKLFRHYYVL IVCYIYFTRI IAFLLKLAVP FQWKWLYQLL DETATLVFFV
541: LTGYKFRPAS DNPYLQLSQE EEDLEMESVV TTSGVMESMK KVKKVTNGSV EPQGEWEGAV