9.A.14.22.6
GPR108 of 543 aas and 7 TMSs. It may play a role in intracellular immune modulation by activating the NF-kappaB response and attenuating the Toll-like-receptor response. It also plays an essential function in adeno-associated virus (AAV)
transduction across multiple serotypes except AAV5. It may play a critical
role in mediating the endosomal virus escape or in the AAV virions
trafficking from endosomes to the nucleus (Dudek et al. 2020).
|
| Accession Number: | Q9NPR9 |
|---|
| Protein Name: | Protein GPR108 |
|---|
| Length: | 543 |
|---|
| Molecular Weight: | 60633.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 7 |
|---|
| Location1 / Topology2 / Orientation3: |
Golgi apparatus1 / Multi-pass membrane protein2 |
|---|
| Substrate |
|
|---|
1: MAVSERRGLG RGSPAEWGQR LLLVLLLGGC SGRIHQLALT GEKRADIQLN SFGFYTNGSL
61: EVELSVLRLG LREAEEKSLL VGFSLSRVRS GRVRSYSTRD FQDCPLQKNS SSFLVLFLIN
121: TKDLQVQVRK YGEQKTLFIF PGLLPEAPSK PGLPKPQATV PRKVDGGGTS AASKPKSTPA
181: VIQGPSGKDK DLVLGLSHLN NSYNFSFHVV IGSQAEEGQY SLNFHNCNNS VPGKEHPFDI
241: TVMIREKNPD GFLSAAEMPL FKLYMVMSAC FLAAGIFWVS ILCRNTYSVF KIHWLMAALA
301: FTKSISLLFH SINYYFINSQ GHPIEGLAVM YYIAHLLKGA LLFITIALIG SGWAFIKYVL
361: SDKEKKVFGI VIPMQVLANV AYIIIESREE GASDYVLWKE ILFLVDLICC GAILFPVVWS
421: IRHLQDASGT DGKVAVNLAK LKLFRHYYVM VICYVYFTRI IAILLQVAVP FQWQWLYQLL
481: VEGSTLAFFV LTGYKFQPTG NNPYLQLPQE DEEDVQMEQV MTDSGFREGL SKVNKTASGR
541: ELL