9.A.14.26.1
Integral membrane protein, GPR180, of 698 aas and 8 probable TMSs with one at the N-terminus and 7 at the C-terminus. This C-terminal domain is homologous to other proteins in this family. This G-protein-coupled receptor modulates gametogenesis via the PKG-mediated signaling cascade in Plasmodium berghei (Wang et al. 2022). Functional conservation of GPR180s in other Plasmodium spp. has been demonstrated (Wang et al. 2022).
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| Accession Number: | Q8I5S0 |
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| Protein Name: | Integral membrane protein GPR180, putative |
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| Length: | 698 |
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| Molecular Weight: | 83620.00 |
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| Species: | Plasmodium falciparum (isolate 3D7) [36329] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MCKSHNYMFT FFLWIVLFFI NEENIQGKVY QGQFYLKKNE KIHYLTKFSC NIGTCQFSIK
61: MKLRDNITAK LLNNYYKLNN KTLKEMENDK DDGNNHNNNK YDDDNNNNNN RSNKLLHMDY
121: DNAYYVLSNQ DLEYIPQRIT LMQDIEQRYV NKNDKCYAFG NLKNSHMFNI PFYFKYSDLV
181: NSKTYNLKNF INNKYSMSFN AIHSELKNNK LLQSEILNYG PILNEKNSNY AYKEIYAKTT
241: HRVHVWFLMF DDCYDNFIRN LKLNIKTKLA YWEYLLHASK KFDISSLNDM DIKQDTSYND
301: FQNEETEKDI YSKENINNNN NNNMNNNMNE KKNKSIFYKS FNFDKITLLE NPKRFLFLEE
361: QFTKSEINDI SFFLKYYQFK KMKNFNNMYN NLYKNGYYEQ VIDYIYQNEG FHIEYEVNIF
421: QTNKSHFSYE LLYSPILTFI LTILYILLIF NYGNTIIQNI TSKSHKHAMI LSVAIVIFIQ
481: LLSNSLLLIH LFVYSKNGIG IEFFKISFNI LNFLAQIIMC TMLLSLSYGF TIFEASFDII
541: LRIKVIFIII TIFHVILVIL DNTYIMETSS KFFDNDNVTG YIIFVLRISL AILYHFNINN
601: LFTMSKITPI RKFLKKLYVY GLFYIFSFPI IFIICYIFDT YWRQRFMLFG TALLQFISTY
661: FITKMSLTNS EYFKVSDMSA SDLPGATSSW FNQKIHTY