9.A.14.3.14
5-hydroxytryptamine receptor 1A, 5HTR1a, of 422 aas and 7 TMSs. G-protein coupled receptor for 5-hydroxytryptamine
(serotonin) also functions as a receptor for various drugs and
psychoactive substances (Harrington et al. 1994). Ligand binding causes a conformation change
that triggers signaling via guanine nucleotide-binding proteins (G
proteins) and modulates the activity of down-stream effectors, such as
adenylate cyclase (Gadgaard and Jensen 2020).
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| Accession Number: | P08908 |
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| Protein Name: | 5-hydroxytryptamine receptor 1A |
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| Length: | 422 |
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| Molecular Weight: | 46107.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
inorganic cation |
|---|
1: MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA VLGNACVVAA
61: IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC
121: TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED
181: RSDPDACTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT
241: RHGASPAPQP KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN
301: SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII MGTFILCWLP
361: FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC
421: RQ