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9.A.14.3.4
Adenosine receptor A1 of 326 aas and 7 TMSs.  The ADORA1 mutation linked to early-onset Parkinson's disease alters adenosine A(1)-A(2A) receptor heteromer formation and function. Possibly, a hyperglutamatergic state secondary to increased constitutive activity and sensitivity to adenosine of A(2A)R not forming heteromers with A(1)R represent a main pathogenetic mechanism of the early onset Parkenson's Disease (EOPD) associated with the G279(7.44)S ADORA1 mutation (Sarasola et al. 2022).

Accession Number:P30542
Protein Name:Adenosine receptor A1
Length:326
Molecular Weight:36512.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 134   
Pfam: PF00001   
KEGG: hsa:134    hsa:134   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0008624 P:induction of apoptosis by extracellular signals
GO:0006954 P:inflammatory response
GO:0007399 P:nervous system development
GO:0006909 P:phagocytosis

References (14)

[1] “Cloning and functional characterization of a human A1 adenosine receptor.”  Libert F.et.al.   1530647
[2] “Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA.”  Townsend-Nicholson A.et.al.   1339301
[3] “Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing.”  Ren H.et.al.   8300646
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
[8] “Cloning and functional characterization of a human A1 adenosine receptor.”  Libert F.et.al.   1530647
[9] “Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA.”  Townsend-Nicholson A.et.al.   1339301
[10] “Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing.”  Ren H.et.al.   8300646
[11] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[12] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[13] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[14] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
Structure:
5N2S   5UEN   6D9H     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA 
61:	LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKMVVT 
121:	PRRAAVAIAG CWILSFVVGL TPMFGWNNLS AVERAWAANG SMGEPVIKCE FEKVISMEYM 
181:	VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL 
241:	FLFALSWLPL HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL 
301:	KIWNDHFRCQ PAPPIDEDLP EERPDD