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9.A.14.4.3
Corticotropin-releasing factor receptor-1, CRHR1. The structure is known (Hollenstein et al. 2013). Structural changes in CRFR1 upon antagonist binding and the role of single nucleotide polymorphisms have been investigated (Latek 2017). This G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin) has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors such as adenylate cyclase. CRHR1 promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. It inhibits the activity of the calcium channel CACNA1H (TC# 1.A.1.11.5) (Tao et al. 2008). Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Accession Number:P34998
Protein Name:Corticotropin-releasing factor receptor 1
Length:444
Molecular Weight:50719.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 1394   
Pfam: PF00002    PF02793   
KEGG: hsa:1394   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015056 F:corticotrophin-releasing factor receptor activity
GO:0005515 F:protein binding
GO:0007565 P:female pregnancy
GO:0006955 P:immune response
GO:0007567 P:parturition

References (11)

[1] “Expression cloning of a human corticotropin-releasing-factor receptor.”  Chen R.et.al.   7692441
[2] “Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors.”  Vita N.et.al.   8243652
[3] “The genomic organization of the human corticotropin-releasing factor type-1 receptor.”  Sakai K.et.al.   9757017
[4] “A variant of the human corticotropin-releasing factor (CRF) receptor: cloning, expression and pharmacology.”  Ross P.C.et.al.   7811272
[5] “A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes.”  Grammatopoulos D.K.et.al.   10598591
[6] “Human protein factory for converting the transcriptome into an in vitro-expressed proteome.”  Goshima N.et.al.   19054851
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor.”  Perrin M.H.et.al.   11425856
[9] “Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor.”  Pal K.et.al.   20966082
[10] “Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1.”  Pioszak A.A.et.al.   18801728
[11] “NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist.”  Grace C.R.et.al.   20843795
Structure:
2L27   3EHS   3EHT   3EHU   4K5Y   4Z9G   6P9X   6PB0     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MGGHPQLRLV KALLLLGLNP VSASLQDQHC ESLSLASNIS GLQCNASVDL IGTCWPRSPA 
61:	GQLVVRPCPA FFYGVRYNTT NNGYRECLAN GSWAARVNYS ECQEILNEEK KSKVHYHVAV 
121:	IINYLGHCIS LVALLVAFVL FLRLRPGCTH WGDQADGALE VGAPWSGAPF QVRRSIRCLR 
181:	NIIHWNLISA FILRNATWFV VQLTMSPEVH QSNVGWCRLV TAAYNYFHVT NFFWMFGEGC 
241:	YLHTAIVLTY STDRLRKWMF ICIGWGVPFP IIVAWAIGKL YYDNEKCWFG KRPGVYTDYI 
301:	YQGPMILVLL INFIFLFNIV RILMTKLRAS TTSETIQYRK AVKATLVLLP LLGITYMLFF 
361:	VNPGEDEVSR VVFIYFNSFL ESFQGFFVSV FYCFLNSEVR SAIRKRWHRW QDKHSIRARV 
421:	ARAMSIPTSP TRVSFHSIKQ STAV