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|---|---|
| Accession Number: | P43220 |
| Protein Name: | Glucagon-like peptide 1 receptor |
| Length: | 463 |
| Molecular Weight: | 53026.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 7 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | |
Cross database links:
| DIP: | DIP-29980N |
|---|---|
| Entrez Gene ID: | 2740 |
| Pfam: | PF00002 PF02793 |
| KEGG: | hsa:2740 |
Gene Ontology
GO:0004967
F:glucagon receptor activity
GO:0006112
P:energy reserve metabolic process
GO:0044281
P:small molecule metabolic process
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References (11)[1] “Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor.” Thorens B.et.al. 8405712 [2] “Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor.” Dillon J.S.et.al. 8404634 [3] “Cloning and functional expression of a human glucagon-like peptide-1 receptor.” Graziano M.P.et.al. 8216285 [4] “Signal transduction of the GLP-1-receptor cloned from a human insulinoma.” van Eyll B.et.al. 7517895 [5] “Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences.” Wei Y.et.al. 7843404 [6] “The DNA sequence and analysis of human chromosome 6.” Mungall A.J.et.al. 14574404 [7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [8] “Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene.” Lankat-Buttgereit B.et.al. 9213353 [9] “Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket.” Mann R.J.et.al. 20869417 | |
| Structure: | |
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MAGAPGPLRL ALLLLGMVGR AGPRPQGATV SLWETVQKWR EYRRQCQRSL TEDPPPATDL 61: FCNRTFDEYA CWPDGEPGSF VNVSCPWYLP WASSVPQGHV YRFCTAEGLW LQKDNSSLPW 121: RDLSECEESK RGERSSPEEQ LLFLYIIYTV GYALSFSALV IASAILLGFR HLHCTRNYIH 181: LNLFASFILR ALSVFIKDAA LKWMYSTAAQ QHQWDGLLSY QDSLSCRLVF LLMQYCVAAN 241: YYWLLVEGVY LYTLLAFSVL SEQWIFRLYV SIGWGVPLLF VVPWGIVKYL YEDEGCWTRN 301: SNMNYWLIIR LPILFAIGVN FLIFVRVICI VVSKLKANLM CKTDIKCRLA KSTLTLIPLL 361: GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI LYCFVNNEVQ LEFRKSWERW 421: RLEHLHIQRD SSMKPLKCPT SSLSSGATAG SSMYTATCQA SCS