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9.A.14.4.8
Pituitary adenylate cyclase-activating polypeptide type 1 receptor

Accession Number:P41586
Protein Name:Pituitary adenylate cyclase-activating polypeptide type I receptor
Length:468
Molecular Weight:53314.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 117   
Pfam: PF00002    PF02793   
KEGG: hsa:117   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0004999 F:vasoactive intestinal polypeptide receptor activity
GO:0007190 P:activation of adenylate cyclase activity
GO:0030154 P:cell differentiation
GO:0007275 P:multicellular organismal development
GO:0048011 P:nerve growth factor receptor signaling pathway
GO:0007283 P:spermatogenesis

References (4)

[1] “Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor.”  Ogi K.et.al.   7902709
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical and genetic map of chromosome 7.”  Stoffel M.et.al.   7851900
[4] “Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.”  Sun C.et.al.   17470806
Structure:
2JOD   3N94   6LPB   6M1H   6M1I   6P9Y     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS SPGCPGMWDN 
61:	ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF GDSNSLDLSD MGVVSRNCTE 
121:	DGWSEPFPHY FDACGFDEYE SETGDQDYYY LSVKALYTVG YSTSLVTLTT AMVILCRFRK 
181:	LHCTRNFIHM NLFVSFMLRA ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN 
241:	YFWLFIEGLY LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN 
301:	DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYLR LARSTLLLIP 
361:	LFGIHYTVFA FSPENVSKRE RLVFELGLGS FQGFVVAVLY CFLNGEVQAE IKRKWRSWKV 
421:	NRYFAVDFKH RHPSLASSGV NGGTQLSILS KSSSQIRMSG LPADNLAT