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9.A.14.6.2
CD97 antigen or adhesion GPCR (aGPCR, ADGRE5), of 835 aas amd 7 C-terminal TMSs, with one possible N-terminal TMS. The protein plays a role in tumorigenesis (Aust et al. 2016).  Maser and Calvet 2020 reviewed structural and functional features shared by polycystin-1 (TC# 1.A.5.1.1) and the adhesion GPCRs and discussed the implications of such similarities for our understanding of the functions of this complicated protein (Thor and Liebscher 2023). The stachel binding site is within the 7TMS domain (Kleinau et al. 2023). The analyses of these authors extend the current view of aGPCR activation and exposes similarities and differences not only between diverse aGPCR members, but also compared to other GPCR classes.

Accession Number:P48960
Protein Name:CD97 antigen
Length:835
Molecular Weight:91869.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Secreted1
Substrate

Cross database links:

DIP: DIP-52292N
Entrez Gene ID: 976   
Pfam: PF00002    PF07645    PF01825   
KEGG: hsa:976   

Gene Ontology

GO:0005615 C:extracellular space
GO:0005887 C:integral to plasma membrane
GO:0005509 F:calcium ion binding
GO:0004930 F:G-protein coupled receptor activity
GO:0007155 P:cell adhesion
GO:0007267 P:cell-cell signaling
GO:0006928 P:cellular component movement
GO:0006955 P:immune response
GO:0006954 P:inflammatory response
GO:0007218 P:neuropeptide signaling pathway

References (13)

[1] “Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain.”  Hamann J.et.al.   7636245
[2] “Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily.”  Hamann J.et.al.   8786105
[3] “CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation.”  Gray J.X.et.al.   8955192
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The DNA sequence and biology of human chromosome 19.”  Grimwood J.et.al.   15057824
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.”  Lin H.-H.et.al.   11297558
[8] “The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans.”  Stacey M.et.al.   12829604
[9] “The EGF-TM7 family: a postgenomic view.”  Kwakkenbos M.J.et.al.   14647991
[10] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[11] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[12] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.”  Chen R.et.al.   19159218
[13] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973
Structure:
2BOU     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MGGRVFLAFC VWLTLPGAET QDSRGCARWC PQNSSCVNAT ACRCNPGFSS FSEIITTPTE 
61:	TCDDINECAT PSKVSCGKFS DCWNTEGSYD CVCSPGYEPV SGAKTFKNES ENTCQDVDEC 
121:	QQNPRLCKSY GTCVNTLGSY TCQCLPGFKF IPEDPKVCTD VNECTSGQNP CHSSTHCLNN 
181:	VGSYQCRCRP GWQPIPGSPN GPNNTVCEDV DECSSGQHQC DSSTVCFNTV GSYSCRCRPG 
241:	WKPRHGIPNN QKDTVCEDMT FSTWTPPPGV HSQTLSRFFD KVQDLGRDSK TSSAEVTIQN 
301:	VIKLVDELME APGDVEALAP PVRHLIATQL LSNLEDIMRI LAKSLPKGPF TYISPSNTEL 
361:	TLMIQERGDK NVTMGQSSAR MKLNWAVAAG AEDPGPAVAG ILSIQNMTTL LANASLNLHS 
421:	KKQAELEEIY ESSIRGVQLR RLSAVNSIFL SHNNTKELNS PILFAFSHLE SSDGEAGRDP 
481:	PAKDVMPGPR QELLCAFWKS DSDRGGHWAT EGCQVLGSKN GSTTCQCSHL SSFAILMAHY 
541:	DVEDWKLTLI TRVGLALSLF CLLLCILTFL LVRPIQGSRT TIHLHLCICL FVGSTIFLAG 
601:	IENEGGQVGL RCRLVAGLLH YCFLAAFCWM SLEGLELYFL VVRVFQGQGL STRWLCLIGY 
661:	GVPLLIVGVS AAIYSKGYGR PRYCWLDFEQ GFLWSFLGPV TFIILCNAVI FVTTVWKLTQ 
721:	KFSEINPDMK KLKKARALTI TAIAQLFLLG CTWVFGLFIF DDRSLVLTYV FTILNCLQGA 
781:	FLYLLHCLLN KKVREEYRKW ACLVAGGSKY SEFTSTTSGT GHNQTRALRA SESGI