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9.A.14.6.8
Adhesion 6 protein-coupled receptor, ADGRL3, or latrophilin-3, LPHN3, of 1447 aas and 7 central TMSs.  It plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (Lu et al. 2015). It also plays a role in the development of glutamatergic synapses in the cortex and determines the connectivity rates between the principal neurons in the cortex.  Knockout of latrophilin-3 in rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers (Regan et al. 2019).  

Accession Number:Q9HAR2
Protein Name:Adhesion G protein-coupled receptor L3
Length:1447
Molecular Weight:161812.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Structure:
5AFB   5CMN   6VHH     

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MWPSQLLIFM MLLAPIIHAF SRAPIPMAVV RRELSCESYP IELRCPGTDV IMIESANYGR 
61:	TDDKICDSDP AQMENIRCYL PDAYKIMSQR CNNRTQCAVV AGPDVFPDPC PGTYKYLEVQ 
121:	YECVPYKVEQ KVFLCPGLLK GVYQSEHLFE SDHQSGAWCK DPLQASDKIY YMPWTPYRTD 
181:	TLTEYSSKDD FIAGRPTTTY KLPHRVDGTG FVVYDGALFF NKERTRNIVK FDLRTRIKSG 
241:	EAIIANANYH DTSPYRWGGK SDIDLAVDEN GLWVIYATEQ NNGKIVISQL NPYTLRIEGT 
301:	WDTAYDKRSA SNAFMICGIL YVVKSVYEDD DNEATGNKID YIYNTDQSKD SLVDVPFPNS 
361:	YQYIAAVDYN PRDNLLYVWN NYHVVKYSLD FGPLDSRSGQ AHHGQVSYIS PPIHLDSELE 
421:	RPSVKDISTT GPLGMGSTTT STTLRTTTLS PGRSTTPSVS GRRNRSTSTP SPAVEVLDDM 
481:	TTHLPSASSQ IPALEESCEA VEAREIMWFK TRQGQIAKQP CPAGTIGVST YLCLAPDGIW 
541:	DPQGPDLSNC SSPWVNHITQ KLKSGETAAN IARELAEQTR NHLNAGDITY SVRAMDQLVG 
601:	LLDVQLRNLT PGGKDSAARS LNKAMVETVN NLLQPQALNA WRDLTTSDQL RAATMLLHTV 
661:	EESAFVLADN LLKTDIVREN TDNIKLEVAR LSTEGNLEDL KFPENMGHGS TIQLSANTLK 
721:	QNGRNGEIRV AFVLYNNLGP YLSTENASMK LGTEALSTNH SVIVNSPVIT AAINKEFSNK 
781:	VYLADPVVFT VKHIKQSEEN FNPNCSFWSY SKRTMTGYWS TQGCRLLTTN KTHTTCSCNH 
841:	LTNFAVLMAH VEVKHSDAVH DLLLDVITWV GILLSLVCLL ICIFTFCFFR GLQSDRNTIH 
901:	KNLCISLFVA ELLFLIGINR TDQPIACAVF AALLHFFFLA AFTWMFLEGV QLYIMLVEVF 
961:	ESEHSRRKYF YLVGYGMPAL IVAVSAAVDY RSYGTDKVCW LRLDTYFIWS FIGPATLIIM 
1021:	LNVIFLGIAL YKMFHHTAIL KPESGCLDNI KSWVIGAIAL LCLLGLTWAF GLMYINESTV 
1081:	IMAYLFTIFN SLQGMFIFIF HCVLQKKVRK EYGKCLRTHC CSGKSTESSI GSGKTSGSRT 
1141:	PGRYSTGSQS RIRRMWNDTV RKQSESSFIT GDINSSASLN REGLLNNARD TSVMDTLPLN 
1201:	GNHGNSYSIA SGEYLSNCVQ IIDRGYNHNE TALEKKILKE LTSNYIPSYL NNHERSSEQN 
1261:	RNLMNKLVNN LGSGREDDAI VLDDATSFNH EESLGLELIH EESDAPLLPP RVYSTENHQP 
1321:	HHYTRRRIPQ DHSESFFPLL TNEHTEDLQS PHRDSLYTSM PTLAGVAATE SVTTSTQTEP 
1381:	PPAKCGDAED VYYKSMPNLG SRNHVHQLHT YYQLGRGSSD GFIVPPNKDG TPPEGSSKGP 
1441:	AHLVTSL