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9.A.14.7.10
Taste receptor TAS1R3, T1R3, TR3 of 852 aas and 7 C-terminal TMSs. TAS1R1/TAS1R3 responds to the umami (amino acid) taste stimuli (the taste of monosodium glutamate) (Li et al. 2002). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (Li et al. 2002), and this heterodimer as well as TAS1R1/TAS1R3 confers sweet-sensing abilities to songbirds (nearly half of all birds) (Toda et al. 2021). TAS1R3 is essential for the recognition and response to the disaccharide trehalose (Ariyasu et al. 2018). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. This receptor may function in a parallel sweet-sensitive pathway, involving signaling mechanisms, neural processing, interactions with endocrine hormonal mechanisms, and sensitivity to different stimuli, and its physiological role in detecting the energy content of food in preparation for digestion (von Molitor et al. 2020).

Accession Number:Q7RTX0
Protein Name:Taste receptor type 1 member 3
Length:852
Molecular Weight:93386.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate alpha,alpha-trehalose, sucrose

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FASTA formatted sequence
1:	MLGPAVLGLS LWALLHPGTG APLCLSQQLR MKGDYVLGGL FPLGEAEEAG LRSRTRPSSP 
61:	VCTRFSSNGL LWALAMKMAV EEINNKSDLL PGLRLGYDLF DTCSEPVVAM KPSLMFLAKA 
121:	GSRDIAAYCN YTQYQPRVLA VIGPHSSELA MVTGKFFSFF LMPQVSYGAS MELLSARETF 
181:	PSFFRTVPSD RVQLTAAAEL LQEFGWNWVA ALGSDDEYGR QGLSIFSALA AARGICIAHE 
241:	GLVPLPRADD SRLGKVQDVL HQVNQSSVQV VLLFASVHAA HALFNYSISS RLSPKVWVAS 
301:	EAWLTSDLVM GLPGMAQMGT VLGFLQRGAQ LHEFPQYVKT HLALATDPAF CSALGEREQG 
361:	LEEDVVGQRC PQCDCITLQN VSAGLNHHQT FSVYAAVYSV AQALHNTLQC NASGCPAQDP 
421:	VKPWQLLENM YNLTFHVGGL PLRFDSSGNV DMEYDLKLWV WQGSVPRLHD VGRFNGSLRT 
481:	ERLKIRWHTS DNQKPVSRCS RQCQEGQVRR VKGFHSCCYD CVDCEAGSYR QNPDDIACTF 
541:	CGQDEWSPER STRCFRRRSR FLAWGEPAVL LLLLLLSLAL GLVLAALGLF VHHRDSPLVQ 
601:	ASGGPLACFG LVCLGLVCLS VLLFPGQPSP ARCLAQQPLS HLPLTGCLST LFLQAAEIFV 
661:	ESELPLSWAD RLSGCLRGPW AWLVVLLAML VEVALCTWYL VAFPPEVVTD WHMLPTEALV 
721:	HCRTRSWVSF GLAHATNATL AFLCFLGTFL VRSQPGCYNR ARGLTFAMLA YFITWVSFVP 
781:	LLANVQVVLR PAVQMGALLL CVLGILAAFH LPRCYLLMRQ PGLNTPEFFL GGGPGDAQGQ 
841:	NDGNTGNQGK HE