9.A.14.7.10
Taste receptor TAS1R3, T1R3, TR3 of 852 aas and 7 C-terminal TMSs. TAS1R1/TAS1R3 responds to the umami (amino acid) taste stimuli
(the taste of monosodium glutamate) (Li et al. 2002). TAS1R2/TAS1R3 recognizes diverse
natural and synthetic sweeteners (Li et al. 2002), and this heterodimer as well as TAS1R1/TAS1R3 confers sweet-sensing abilities to songbirds (nearly half of all birds) (Toda et al. 2021). TAS1R3 is essential for the
recognition and response to the disaccharide trehalose (Ariyasu et al. 2018).
Sequence differences within and between species can significantly
influence the selectivity and specificity of taste responses. This receptor may function in a parallel sweet-sensitive pathway, involving signaling mechanisms, neural
processing, interactions with endocrine hormonal mechanisms, and sensitivity to different stimuli, and its physiological
role in detecting the energy content of food in preparation for
digestion (von Molitor et al. 2020).
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| Accession Number: | Q7RTX0 |
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| Protein Name: | Taste receptor type 1 member 3 |
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| Length: | 852 |
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| Molecular Weight: | 93386.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
alpha,alpha-trehalose, sucrose |
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1: MLGPAVLGLS LWALLHPGTG APLCLSQQLR MKGDYVLGGL FPLGEAEEAG LRSRTRPSSP
61: VCTRFSSNGL LWALAMKMAV EEINNKSDLL PGLRLGYDLF DTCSEPVVAM KPSLMFLAKA
121: GSRDIAAYCN YTQYQPRVLA VIGPHSSELA MVTGKFFSFF LMPQVSYGAS MELLSARETF
181: PSFFRTVPSD RVQLTAAAEL LQEFGWNWVA ALGSDDEYGR QGLSIFSALA AARGICIAHE
241: GLVPLPRADD SRLGKVQDVL HQVNQSSVQV VLLFASVHAA HALFNYSISS RLSPKVWVAS
301: EAWLTSDLVM GLPGMAQMGT VLGFLQRGAQ LHEFPQYVKT HLALATDPAF CSALGEREQG
361: LEEDVVGQRC PQCDCITLQN VSAGLNHHQT FSVYAAVYSV AQALHNTLQC NASGCPAQDP
421: VKPWQLLENM YNLTFHVGGL PLRFDSSGNV DMEYDLKLWV WQGSVPRLHD VGRFNGSLRT
481: ERLKIRWHTS DNQKPVSRCS RQCQEGQVRR VKGFHSCCYD CVDCEAGSYR QNPDDIACTF
541: CGQDEWSPER STRCFRRRSR FLAWGEPAVL LLLLLLSLAL GLVLAALGLF VHHRDSPLVQ
601: ASGGPLACFG LVCLGLVCLS VLLFPGQPSP ARCLAQQPLS HLPLTGCLST LFLQAAEIFV
661: ESELPLSWAD RLSGCLRGPW AWLVVLLAML VEVALCTWYL VAFPPEVVTD WHMLPTEALV
721: HCRTRSWVSF GLAHATNATL AFLCFLGTFL VRSQPGCYNR ARGLTFAMLA YFITWVSFVP
781: LLANVQVVLR PAVQMGALLL CVLGILAAFH LPRCYLLMRQ PGLNTPEFFL GGGPGDAQGQ
841: NDGNTGNQGK HE