9.A.14.7.9
Glutamate metabolomic receptor 2, Grm2, of 872 aas with 1 N-terminal and 7 C-terminal TMSs. Ligand binding causes a conformation change that
triggers signaling via guanine nucleotide-binding proteins (G proteins)
and modulates the activity of down-stream effectors, such as adenylate
cyclase. Signaling inhibits adenylate cyclase activity (Flor et al. 1995). It may mediate
suppression of neurotransmission or may be involved in synaptogenesis or
synaptic stabilization. It forms a complex with the serotonin receptor (González-Maeso et al. 2008) as well as with SNAT6, the glutamate/glutamine transporter (Gandasi et al. 2021).
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| Accession Number: | Q14416 |
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| Protein Name: | Metabotropic glutamate receptor 2 |
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| Length: | 872 |
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| Molecular Weight: | 95568.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MGSLLALLAL LLLWGAVAEG PAKKVLTLEG DLVLGGLFPV HQKGGPAEDC GPVNEHRGIQ
61: RLEAMLFALD RINRDPHLLP GVRLGAHILD SCSKDTHALE QALDFVRASL SRGADGSRHI
121: CPDGSYATHG DAPTAITGVI GGSYSDVSIQ VANLLRLFQI PQISYASTSA KLSDKSRYDY
181: FARTVPPDFF QAKAMAEILR FFNWTYVSTV ASEGDYGETG IEAFELEARA RNICVATSEK
241: VGRAMSRAAF EGVVRALLQK PSARVAVLFT RSEDARELLA ASQRLNASFT WVASDGWGAL
301: ESVVAGSEGA AEGAITIELA SYPISDFASY FQSLDPWNNS RNPWFREFWE QRFRCSFRQR
361: DCAAHSLRAV PFEQESKIMF VVNAVYAMAH ALHNMHRALC PNTTRLCDAM RPVNGRRLYK
421: DFVLNVKFDA PFRPADTHNE VRFDRFGDGI GRYNIFTYLR AGSGRYRYQK VGYWAEGLTL
481: DTSLIPWASP SAGPLPASRC SEPCLQNEVK SVQPGEVCCW LCIPCQPYEY RLDEFTCADC
541: GLGYWPNASL TGCFELPQEY IRWGDAWAVG PVTIACLGAL ATLFVLGVFV RHNATPVVKA
601: SGRELCYILL GGVFLCYCMT FIFIAKPSTA VCTLRRLGLG TAFSVCYSAL LTKTNRIARI
661: FGGAREGAQR PRFISPASQV AICLALISGQ LLIVVAWLVV EAPGTGKETA PERREVVTLR
721: CNHRDASMLG SLAYNVLLIA LCTLYAFKTR KCPENFNEAK FIGFTMYTTC IIWLAFLPIF
781: YVTSSDYRVQ TTTMCVSVSL SGSVVLGCLF APKLHIILFQ PQKNVVSHRA PTSRFGSAAA
841: RASSSLGQGS GSQFVPTVCN GREVVDSTTS SL