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9.A.14.8.3
Olfactory receptor OR51E2 of 320 aas and 7 TMSs. This olfactory receptor (Jovancevic et al. 2017) is activated by the odorant, beta-ionone, a synthetic terpenoid (Neuhaus et al. 2009). Its activity is propably mediated by G-proteins leading to the elevation of intracellular Ca2+, cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (Gelis et al. 2016). Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis and increases proliferation and migration of primary retinal pigment epithelial  cells (Jovancevic et al. 2017). Activation by the short-chain fatty acids (SCFA), acetate,  L-lactate and propionate, may positively regulate renin secretion and increase blood pressure (Pluznick et al. 2013). It may also be activated by steroid hormones and regulate cell proliferation (Neuhaus et al. 2009). Its activity is propably mediated by G-proteins leading to the elevation of intracellular Ca2+, cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (Gelis et al. 2016). Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis and increases proliferation and migration of primary retinal pigment epithelial  cells (Jovancevic et al. 2017). Activation by the short-chain fatty acids (SCFA), acetate,  L-lactate and propionate, may positively regulate renin secretion and increase blood pressure (Pluznick et al. 2013). It may also be activated by steroid hormones and regulate cell proliferation (Neuhaus et al. 2009). 

Accession Number:Q9H255
Protein Name:Olfactory receptor 51E2
Length:320
Molecular Weight:35493.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

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FASTA formatted sequence
1:	MSSCNFTHAT FVLIGIPGLE KAHFWVGFPL LSMYVVAMFG NCIVVFIVRT ERSLHAPMYL 
61:	FLCMLAAIDL ALSTSTMPKI LALFWFDSRE ISFEACLTQM FFIHALSAIE STILLAMAFD 
121:	RYVAICHPLR HAAVLNNTVT AQIGIVAVVR GSLFFFPLPL LIKRLAFCHS NVLSHSYCVH 
181:	QDVMKLAYAD TLPNVVYGLT AILLVMGVDV MFISLSYFLI IRTVLQLPSK SERAKAFGTC 
241:	VSHIGVVLAF YVPLIGLSVV HRFGNSLHPI VRVVMGDIYL LLPPVINPII YGAKTKQIRT 
301:	RVLAMFKISC DKDLQAVGGK