9.A.29.3.4
Serine incorporator 3 of 473 aas and 11 TMSs. May exhibit L-serine transmembrane transport activity. Restriction factor required to restrict
infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early
step of viral infection. Impairs the penetration of the viral particle
into the cytoplasm (Usami et al. 2015).
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| Accession Number: | Q13530 |
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| Protein Name: | Serine incorporator 3 |
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| Length: | 473 |
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| Molecular Weight: | 52580.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
serine |
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1: MGAVLGVFSL ASWVPCLCSG ASCLLCSCCP NSKNSTVTRL IYAFILLLST VVSYIMQRKE
61: METYLKKIPG FCEGGFKIHE ADINADKDCD VLVGYKAVYR ISFAMAIFFF VFSLLMFKVK
121: TSKDLRAAVH NGFWFFKIAA LIGIMVGSFY IPGGYFSSVW FVVGMIGAAL FILIQLVLLV
181: DFAHSWNESW VNRMEEGNPR LWYAALLSFT SAFYILSIIC VGLLYTYYTK PDGCTENKFF
241: ISINLILCVV ASIISIHPKI QEHQPRSGLL QSSLITLYTM YLTWSAMSNE PDRSCNPNLM
301: SFITRITAPT LAPGNSTAVV PTPTPPSKSG SLLDSDNFIG LFVFVLCLLY SSIRTSTNSQ
361: VDKLTLSGSD SVILGDTTTS GASDEEDGQP RRAVDNEKEG VQYSYSLFHL MLCLASLYIM
421: MTLTSWYSPD AKFQSMTSKW PAVWVKISSS WVCLLLYVWT LVAPLVLTSR DFS