| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
9.A.29.1.1 |
LanG is a Lantibiotic immunity protein. It may or may not function with LanEF (an ABC antibiotic exporter; TC 3.A.1.131.2) (Okuda et al., 2010). The 6 TMSs of LanG show sequence similarity with TMSs 6-10 of DME family proteins (see 2.A.7.3.17).
| Bacteria |
Bacillota | LanG of Bacillus licheniformis (A5A639) |
|
9.A.29.2.1 | Uncharacterized protein of 445 aas and 11 TMSs | Bacteria |
Bacteroidota | UP of Bacteroides sp. |
|
9.A.29.2.2 | Uncharacterized protein of 393 aas and 7 - 9 TMSs. | Bacteria |
Acidobacteriota | UP of Acidobacteria bacterium (soil metagenome) |
|
9.A.29.2.3 | Uncharacterized protein of 486 aas and 9 TMSs. | Bacteria |
UP of a bacterium | |
|
9.A.29.2.4 | Uncharacterized protein of 427 aas and 9 or 10 TMSs in a 5 or 6 + 3 TMS arrangement. | Archaea |
Candidatus Woesearchaeota | UP of Candidatus Woesearchaeota archaeon (groundwater metagenome) |
|
9.A.29.3.1 | Uncharacterized protein of 441 aas and 11 TMSs. | Eukaryota |
Fungi, Ascomycota | UP of Schizosaccharomyces pombe (Fission yeast) |
|
9.A.29.3.2 | Uncharacterized NTF2 domain-containing protein of 528 aas and 8 TMSs in a 6 + 2 arrangement (Krapp et al. 2017). | Eukaryota |
Viridiplantae, Streptophyta | UP of Arabidopsis thaliana (Mouse-ear cress) |
|
9.A.29.3.3 | Serine incorporator 5, SERINC5, of 708 aas and 7 - 10 TMSs. | Eukaryota |
Metazoa, Platyhelminthes | SERINC5 of Clonorchis sinensis (Chinese liver fluke) |
|
9.A.29.3.4 | Serine incorporator 3 of 473 aas and 11 TMSs. May exhibit L-serine transmembrane transport activity. Restriction factor required to restrict
infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early
step of viral infection. Impairs the penetration of the viral particle
into the cytoplasm (Usami et al. 2015). | Eukaryota |
Metazoa, Chordata | Serinc3 of Homo sapiens |
|
9.A.29.3.5 | Serine incorporator 5, SERINC5, of 423 aas and 10 or 11 TMSs. The 3-D structure has been determined (Pye et al. 2020). See paragraph 2 in the family description for details. SERINC5 and IFITM3 block fusioin of HIV-1 envelope glycoprotein with the cell membrane during the course of HIV-1, but at different stages of viral infection (Beitari et al. 2020).
| Eukaryota |
Metazoa, Chordata | SERINC5 of Homo sapiens |