9.A.29.3.5
Serine incorporator 5, SERINC5, of 423 aas and 10 or 11 TMSs. The 3-D structure has been determined (Pye et al. 2020). See paragraph 2 in the family description for details. SERINC5 and IFITM3 block fusioin of HIV-1 envelope glycoprotein with the cell membrane during the course of HIV-1, but at different stages of viral infection (Beitari et al. 2020).
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| Accession Number: | Q86VE9 |
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| Protein Name: | Serine incorporator 5 |
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| Length: | 423 |
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| Molecular Weight: | 47009.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MSAQCCAGQL ACCCGSAGCS LCCDCCPRIR QSLSTRFMYA LYFILVVVLC CIMMSTTVAH
61: KMKEHIPFFE DMCKGIKAGD TCEKLVGYSA VYRVCFGMAC FFFIFCLLTL KINNSKSCRA
121: HIHNGFWFFK LLLLGAMCSG AFFIPDQDTF LNAWRYVGAV GGFLFIGIQL LLLVEFAHKW
181: NKNWTAGTAS NKLWYASLAL VTLIMYSIAT GGLVLMAVFY TQKDSCMENK ILLGVNGGLC
241: LLISLVAISP WVQNRQPHSG LLQSGVISCY VTYLTFSALS SKPAEVVLDE HGKNVTICVP
301: DFGQDLYRDE NLVTILGTSL LIGCILYSCL TSTTRSSSDA LQGRYAAPEL EIARCCFCFS
361: PGGEDTEEQQ PGKEGPRVIY DEKKGTVYIY SYFHFVFFLA SLYVMMTVTN WFNHVRSAFH
421: LLP