TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.A.49.1.1









Prenylated Rab acceptor protein 1 (PRA1, prenylin, yip3) of 185 aas and 3 - 4 putative TMSs. The C-terminus of prenylin is important in forming a dimer conformation necessary for endoplasmic-reticulum-to-Golgi transport (Liang et al. 2004). It may play a role in postnatal development of the inner retina (Dickison et al. 2012).

Eukaryota
Metazoa, Chordata
PRA1 of Homo sapiens
9.A.49.1.2









Prenylated Rab acceptor protein 2 (PRAF2; JM4) of 178 aas and 4 TMSs in a 2 + 2 TMS arrangement. Its expression profiles and characteristics have been described (Fo et al. 2006; Koomoa et al. 2008). JM4 interacts with the CC chemokine receptor 5 (CCR5), a major co-receptor for human immunodeficiency virus (HIV); CCR5 mutants lacking the carboxy (C)-terminus interfere with HIV infection (Schweneker et al. 2005). JM4, JWA (TC# 9.A.49.1.3), and GTRAP3-18 co-localise and heterodimerise indicating a functional relationship. JM4 co-localizes with calnexin in the endoplasmic reticulum and with the mannose 6-phosphate receptor in the Golgi. JM4 and GTRAP3-18 harbor a Rab-acceptor motif, indicating a function in vesicle formation in the Golgi. The cinokex may function in trafficking and membrane localization of CCR5 receptor, and possibly other receptors or amino acid transporters (Schweneker et al. 2005).  It may be involved in ER/Golgi transport and vesicular traffic, and it plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis (Geerts et al. 2007). It is involved in  control of CCR5 cell-surface targeting (Da Silva et al. 2023).

Eukaryota
Metazoa, Chordata
PRAF2 of Homo sapiens
9.A.49.1.3









PRAF3 of 188 aas and 4 TMSs.  It is also called PRA2, GTRAP3-18, JWA, ARL6IP5, DERP11, and Ar16-IP5. JWA, like JM4 (TC# 9.A.49.1.2), is a four TMS protein, which binds to the CCR5 receptor (Schweneker et al. 2005). JM4, JWA, and GTRAP3-18 co-localize and heterodimerize, indicating a functional relationship. JM4 co-localises with calnexin in the endoplasmic reticulum and with the mannose 6-phosphate receptor in the Golgi. JM4 and GTRAP3-18 harbor a Rab-acceptor motif, indicating a function in vesicle formation in the Golgi complex.Thus, Schweneker et al. 2005 demonstrated CCR5-interacting proteins, suggesting a function in trafficking and membrane localization of the receptor, possibly as well as other receptors and amino acid transporters.

Eukaryota
Metazoa, Chordata
PRAF3 of Homo sapiens
9.A.49.1.4









PRA1 family protein B1

Eukaryota
Viridiplantae, Streptophyta
Protein B1 of Arabidopsis thaliana (Mouse-ear cress)
9.A.49.1.5









PrafB of 158 aas and 4 TMSs.

Eukaryota
Evosea
PrafB of Polysphondylium pallidum (Cellular slime mold)
9.A.49.1.6









RAB interacting protein of 206 aas

Eukaryota
Euglenozoa
Pro1 family member of Trypanosoma vivax
9.A.49.1.7









Uncharacterized protein of 197 aas

Eukaryota
Euglenozoa
UP of Leishmania braziliensis
9.A.49.1.8









Prenylated rab acceptor 1 of 230 aas

Eukaryota
Discosea
Prenylated rab acceptor 1 of Acanthamoeba castellanii
9.A.49.1.9









Uncharacterized protein of 177 aas

Eukaryota
Viridiplantae, Chlorophyta
UP of Micromonas pusilla (Picoplanktonic green alga)
9.A.49.1.10









PRA1 family protein 2, Praf2 of 158 aas

Eukaryota
Evosea
Praf2 of Dictyostelium discoideum (Slime mold)
9.A.49.1.11









RAB acceptor of 226 aas, Cgd8

Eukaryota
Apicomplexa
Cgd8 of Cryptosporidium parvum
9.A.49.1.12









Yip3 or PRA3 of 176 aas and 2 or 3 TMSs (Tanimoto et al. 2011).

Eukaryota
Fungi, Ascomycota
Yip3 of Saccharomyces cerevisiae (Baker's yeast)