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9.A.50 The Nuclear t-RNA Exporter (tRNA-E) Family

tRNAs are made in the nucleolus of the nuclei of eukaryotes. They are processed and exported into the cytoplasm. The t-exporter consists of several proteins. The protein t-UTP8 acts between maturation and translocation across the nuclear pore complex. It interacts with the two tRNA export receptors, Los1 and Msn5, and the Ran GTPase, Gsp1 t-UTP8, probably transfers tRNA to the nuclear tRNA export receptors by using a channeling mechanism (Strub et al., 2007). Importins and exportins have been reviewed (Ding and Sepehrimanesh 2021; Azmi et al. 2021). These proteins are also tabulated under TC# 1.I.1.1.3 as part of the nuclear pore complex.

The transport reaction catalyzes by a tRNA-exporter is:

tRNA (nucleus) → tRNA (cytoplasm)

References associated with 9.A.50 family:

Azmi, A.S., M.H. Uddin, and R.M. Mohammad. (2021). The nuclear export protein XPO1 - from biology to targeted therapy. Nat Rev Clin Oncol 18: 152-169. 33173198
Ding, B. and M. Sepehrimanesh. (2021). Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration. Int J Mol Sci 22:. 33920577
Strub, B.R., M.B. Eswara, J.B. Pierce, and D. Mangroo. (2007). Utp8p is a nucleolar tRNA-binding protein that forms a complex with components of the nuclear tRNA export machinery in Saccharomyces cerevisiae. Mol. Biol. Cell 18: 3845-3859. 17634288