| TCID | Name | Domain | Kingdom/Phylum | Protein(s) | ||
|---|---|---|---|---|---|---|
|
9.A.54.1.1 | Probable lysosomal cobalamin exporter, NESI or C61F disease protein; defective in cobalamin F type disease (540aas; 9 TMSs in a 5 + 4 arrangement) (Ruivo et al., 2009; Rutsch et al., 2009; Gailus et al., 2010; Wilcken, 2012; Braz et al. 2022) (also called LMBR1 domain-containing protein or LMBRD1; liver regeneration p53-related protein, Lipocalin-interacting membrane receptor, limb region 1 protein, etc.) Homologues are present in all eukaryotes and probably some bacteria (e.g., EcsB protein of Bacillus cereus (gi#47570159; 10 TMSs; distantly related to 3.A.1.128.2). RodA of E. coli (9.B.3.1.2) may also be distantly related. | Eukaryota |
Metazoa, Chordata | NESI of Homo sapiens (Q9NUN5) | ||
|
9.A.54.1.2 | Probable lysosomal cobalamin transporter of 646 aas and 7 TMSs in a 5 + 2 + hydrophilic domain arrangement. | Eukaryota |
Fungi, Ascomycota | CHGG_01714 of Chaetomium globosum | ||
|
9.A.54.1.3 | Probable lysosomal cobalamine exporter of 590 aas and 9 putative TMSs. | Eukaryota |
Fungi | Cobalamine exporter of Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum) | ||
|
9.A.54.1.4 | Conserved plant hypothetical protein (9 TMSs) | Eukaryota |
Viridiplantae, Streptophyta | Hypothetical protein of Ricinus communis (B9SQ26) | ||
|
9.A.54.1.5 | Uncharacterized protein of 476 aas and 9 TMSs in a 5 + 4 arrangement. | Eukaryota |
Euglenozoa | UP of Trypanosoma cruzi | ||
|
9.A.54.2.1 | Hypothetical alveolata protein conserved in Plasmodium species, of 585 aas and 9 TMSs in a 5 + 4 arrangement). | Eukaryota |
Apicomplexa | Hypothetical protein of Plasmodium knowlesi (B3L7M4)
| ||
|
9.A.54.3.1 | LMBR1-like conserved protein of 612 aas and 9 TMSs in a 5 + 4 TMS arrangement. | Eukaryota |
Ciliophora | LMBR1-like protein of Tetrahymena thermophila (Q22WA5) | ||
|
9.A.54.3.2 | Uncharacterized protein of 609 aas and 9 TMSs in a 5 + 4 TMS arrangement. | Eukaryota |
Fungi, Ascomycota | UP of Torulaspora delbrueckii (Candida colliculosa) | ||
|
9.A.54.3.3 | Uncharacterized protein of 741 aas and 9 or 10 TMSs in a 5 + 4 or 5 TMS. | Eukaryota |
Rhodophyta | UP of Cyanidioschyzon merolae | ||
|
9.A.54.3.4 | LMBR1 protein homologue of 537 aas | Eukaryota |
Viridiplantae, Chlorophyta | LMBR1 homologue of Ostreococcus tauri | ||
|
9.A.54.3.5 | G-protein coupled receptor-associated protein, LMBRD2, of 695 aas and 8 TMSs in a 2 + 2 + 4 TMS arrangement. De novo missense variants in LMBRD2 are associated with developmental and motor delays, brain structure abnormalities and dysmorphic features (Malhotra et al. 2021). it is a potential regulator of beta2 adrenoceptor signaling (Paek et al. 2017). | Eukaryota |
Metazoa, Chordata | LMBRD2 of Homo sapiens |