9.A.54.3.5
G-protein coupled receptor-associated protein, LMBRD2, of 695 aas and 8 TMSs in a 2 + 2 + 4 TMS arrangement. De novo missense variants in LMBRD2 are associated with developmental and motor delays, brain structure abnormalities and dysmorphic features (Malhotra et al. 2021). it is a potential regulator of beta2 adrenoceptor signaling (Paek et al. 2017).
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| Accession Number: | Q68DH5 |
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| Protein Name: | G-protein coupled receptor-associated protein LMBRD2 |
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| Length: | 695 |
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| Molecular Weight: | 81172.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSGAALGLEI VFVFFLALFL LHRYGDFKKQ HRLVIIGTLL AWYLCFLIVF ILPLDVSTTI
61: YNRCKHAAAN SSPPENSNIT GLYATANPVP SQHPCFKPWS YIPDGIMPIF WRVVYWTSQF
121: LTWILLPFMQ SYARSGGFSI TGKIKTALIE NAIYYGTYLL IFGAFLIYVA VNPHLHLEWN
181: QLQTIGIAAA NTWGLFLLVL LLGYGLVEIP RSYWNGAKRG YLLMKTYFKA AKLMTEKADA
241: EENLEDAMEE VRKVNESIKY NHPLRKCVDT ILKKCPTEYQ EKMGRNMDDY EDFDEKHSIY
301: PSEKSLVKLH KQVIYSVQRH RRTQVQWQIL LEQAFYLEDV AKNETSATHQ FVHTFQSPEP
361: ENRFIQYFYN PTFEWYWECL LRPWFYKILA VVLSIFSVIV VWSECTFFST TPVLSLFAVF
421: IQLAEKTYNY IYIEIACFLS IFFLSICVYS TVFRIRVFNY YYLASHHQTD AYSLLFSGML
481: FCRLTPPLCL NFLGLTHMDS SISHKNTQPT AYTSIMGSMK VLSFIADGFY IYYPMLVVIL
541: CIATYFSLGT RCLNLLGFQQ FMGDDDMTSD LVNEGKELIR KEKRKRQRQE EGENRRREWK
601: ERYGHNREDS TRNRNIHTDP KESNFSDVNT NRSAFKYTRA NNRTERDRIE LLQDAEPLDF
661: NAETFTDDPL ESESGRYQPG GRYLSMSRSD IFNDV