TCDB is operated by the Saier Lab Bioinformatics Group

9.A.61 The Domain of Unknown Function 3339 (DUF3339) Family 

The DUF3339 domain is 68 aas in length. It is predicted to contain two transmembrane domains of 20 and 23 residues each but no cleavable signal peptide. Interestingly, several virus sequences have two tandem copies of the gene (4 predicted TMSs), and several larger proteins (enzymes; structural and regulatory proteins) have the DUF3339 domain either N- or C-terminal to the rest of these proteins.  Representative sequences of the protein itself ((9.A.61.1.1 - 1.3) or fused structures (9.A.61.2.1 and 3.1) as well as duplicated viral proteins with 4 TMSs (9.A.61.4.1) are included as family members. Most if not all family members are derived from plants and related organisms.

References associated with 9.A.61 family:

Hartman, J.J., J. Mahr, K. McNally, K. Okawa, A. Iwamatsu, S. Thomas, S. Cheesman, J. Heuser, R.D. Vale, and F.J. McNally. (1998). Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Cell 93: 277-287. 9568719
McNally, K.P., O.A. Bazirgan, and F.J. McNally. (2000). Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. J Cell Sci 113(Pt9): 1623-1633. 10751153
Xu, C., W. Su, and X. Jiang. (2020). Identification of Differentially Expressed Genes and Signaling Pathways in Glioma by Integrated Bioinformatics Analysis. J Craniofac Surg 31: 2360-2363. 33136891
Yang, Y., A.H. Kim, T. Yamada, B. Wu, P.M. Bilimoria, Y. Ikeuchi, N. de la Iglesia, J. Shen, and A. Bonni. (2009). A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science 326: 575-578. 19900895