9.A.63.1.4
The VPS10 domain-containing receptor SorCS3 of 1222 aas and 2 TMSs, also called the sortilin-related VPS10 domain-containing receptor 3. It is a type-I receptor transmembrane protein and a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined as having a vacuolar protein sorting 10 domain at the N-terminus. members of this family play important roles as sorting agents within the cells and transport a variety of intracellular proteins between the Golgi apparatus, endosome, lysosome, secretory granules, and plasma membrane (Alfadhel et al. 2018).
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| Accession Number: | Q9UPU3 |
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| Protein Name: | VPS10 domain-containing receptor SorCS3 |
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| Length: | 1222 |
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| Molecular Weight: | 135755.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MEAARTERPA GRPGAPLVRT GLLLLSTWVL AGAEITWDAT GGPGRPAAPA SRPPALSPLS
61: PRAVASQWPE ELASARRAAV LGRRAGPELL PQQGGGRGGE MQVEAGGTSP AGERRGRGIP
121: APAKLGGARR SRRAQPPITQ ERGDAWATAP ADGSRGSRPL AKGSREEVKA PRAGGSAAED
181: LRLPSTSFAL TGDSAHNQAM VHWSGHNSSV ILILTKLYDF NLGSVTESSL WRSTDYGTTY
241: EKLNDKVGLK TVLSYLYVNP TNKRKIMLLS DPEMESSILI SSDEGATYQK YRLTFYIQSL
301: LFHPKQEDWV LAYSLDQKLY SSMDFGRRWQ LMHERITPNR FYWSVAGLDK EADLVHMEVR
361: TTDGYAHYLT CRIQECAETT RSGPFARSID ISSLVVQDEY IFIQVTTSGR ASYYVSYRRE
421: AFAQIKLPKY SLPKDMHIIS TDENQVFAAV QEWNQNDTYN LYISDTRGIY FTLAMENIKS
481: SRGLMGNIII ELYEVAGIKG IFLANKKVDD QVKTYITYNK GRDWRLLQAP DVDLRGSPVH
541: CLLPFCSLHL HLQLSENPYS SGRISSKETA PGLVVATGNI GPELSYTDIG VFISSDGGNT
601: WRQIFDEEYN VWFLDWGGAL VAMKHTPLPV RHLWVSFDEG HSWDKYGFTS VPLFVDGALV
661: EAGMETHIMT VFGHFSLRSE WQLVKVDYKS IFSRHCTKED YQTWHLLNQG EPCVMGERKI
721: FKKRKPGAQC ALGRDHSGSV VSEPCVCANW DFECDYGYER HGESQCVPAF WYNPASPSKD
781: CSLGQSYLNS TGYRRIVSNN CTDGLREKYT AKAQMCPGKA PRGLHVVTTD GRLVAEQGHN
841: ATFIILMEEG DLQRTNIQLD FGDGIAVSYA NFSPIEDGIK HVYKSAGIFQ VTAYAENNLG
901: SDTAVLFLHV VCPVEHVHLR VPFVAIRNKE VNISAVVWPS QLGTLTYFWW FGNSTKPLIT
961: LDSSISFTFL AEGTDTITVQ VAAGNALIQD TKEIAVHEYF QSQLLSFSPN LDYHNPDIPE
1021: WRKDIGNVIK RALVKVTSVP EDQILIAVFP GLPTSAELFI LPPKNLTERR KGNEGDLEQI
1081: VETLFNALNQ NLVQFELKPG VQVIVYVTQL TLAPLVDSSA GHSSSAMLML LSVVFVGLAV
1141: FLIYKFKRKI PWINIYAQVQ HDKEQEMIGS VSQSENAPKI TLSDFTEPEE LLDKELDTRV
1201: IGGIATIANS ESTKEIPNCT SV