9.A.70 The Mitochondrial Aspartate Amino Transferase (AAT) Family
The mitochondrial AAT (GOT2) catalyzes the irreversible transamination of the L-tryptophan metabolite, L-kynurenine, to form kynurenic acid (KA), playing a key role in amino acid metabolism. It is important for metabolite exchange between mitochondria and cytosol and facilitates cellular uptake of long-chain free fatty acids (Zhou et al. 1998). It is regulated by AS160 which generally regulates energy utilization including Glut4 translocation to the plasma membrane (Mikłosz et al. 2016).