TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.A.78.1.1









Membrane-associated phosphatidylinositol transfer protein 1, PITPNM1, of 1244 aas and possibly 8 TMSs in a 4 + 4 TMS arrangement. It catalyzes the transfer of phosphatidylinositol (PI) between membranes (Garner et al. 2012, Fullwood et al. 1999). It binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (Garner et al. 2012) and regulates RHOA activity while playing a role in cytoskeleton remodeling (Tian et al. 2002). It is necessary for normal completion of cytokinesis (Litvak et al. 2004) and plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (Litvak et al. 2005). It seems to be necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (Amarilio et al. 2005) and is required for protein export from the endoplasmic reticulum and the Golgi (Litvak et al. 2005). It binds calcium ions (Lev et al. 1999).

Eukaryota
Opisthokonta
PITPNM1 of Homo sapiens
9.A.78.1.2









Protein retinal degeneration B, RdgB, of 1259 aas, possibly with a central 8 TMSs unit in a 4 + 4  TMS arrangement. It catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (Garner et al. 2012).  It may control the phosphatidylinositol concentration in transport vesicles from the subrhabdomeric cisternae (SRC) to the rhabdomere as well as functioning as a calcium transporter (Vihtelic et al. 1991).

Eukaryota
Opisthokonta
RdgB of Drosophila melanogaster (Fruit fly)
9.A.78.1.3









Phospholipase DDHD1 isoform X3 of 621 aas and possibly 4 C-terminal TMSs.

Eukaryota
Opisthokonta
DDHD1 of Leptonychotes weddellii
9.A.78.1.4









Phospholipase DDHD2 isoform X5 of 732 aas and ? TMSs.

Eukaryota
Opisthokonta
DDHD2.5 of Oryzias melastigma
9.A.78.1.5









Putative phosphatase of 995 aas and possibly 4 central TMSs.

Eukaryota
Opisthokonta
Phosphatase of Colletotrichum viniferum
9.A.78.1.6









DDHD-domain-containing protein of 677 aas and possibly 4 central TMSs.

Eukaryota
Sar
Possible phosphatase of Fragilariopsis cylindrus